PNU-282,987 (CAS 123464-89-1)
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PNU-282,987 is a chemical compound extensively used in neuroscience research due to its role as a selective agonist for the α7 nicotinic acetylcholine receptor. It serves as a critical tool in the study of cholinergic signaling, which has implications for understanding cognitive functions such as learning and memory. Researchers utilize PNU-282,987 to explore the underlying mechanisms of neural communication and to investigate the potential modulation of these pathways. In addition, PNU-282,987 is employed in examining the receptor′s involvement in neuroinflammatory responses, as the α7 receptor has been implicated in modulating the release of various cytokines. The compound′s specificity for the α7 receptor makes it particularly useful for discerning the discrete roles that different nicotinic receptors play in neural function and pathology.
PNU-282,987 (CAS 123464-89-1) References
- The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. | Hajós, M., et al. 2005. J Pharmacol Exp Ther. 312: 1213-22. PMID: 15523001
- Activation of alpha7 acetylcholine receptors augments stimulation-induced hippocampal theta oscillation. | Siok, CJ., et al. 2006. Eur J Neurosci. 23: 570-4. PMID: 16420464
- Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. | Su, X., et al. 2007. Am J Respir Cell Mol Biol. 37: 186-92. PMID: 17431097
- Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor. | Waldburger, JM., et al. 2008. Arthritis Rheum. 58: 3439-49. PMID: 18975306
- The role of nicotinic acetylcholine receptor (nAChR) α7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum. | Taslim, N. and Saeed Dar, M. 2011. Alcohol Clin Exp Res. 35: 540-9. PMID: 21143250
- Selective α4β2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons. | Maloku, E., et al. 2011. Neuropsychopharmacology. 36: 1366-74. PMID: 21368748
- Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711). | Bréthous, L., et al. 2012. J Med Chem. 55: 4605-18. PMID: 22591063
- Nicotinic agonist-induced improvement of vigilance in mice in the 5-choice continuous performance test. | Young, JW., et al. 2013. Behav Brain Res. 240: 119-33. PMID: 23201359
- Exploring α7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB. | Garcia-Delgado, N., et al. 2010. ACS Med Chem Lett. 1: 422-6. PMID: 24900227
- Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression. | Siniavin, AE., et al. 2020. Biomolecules. 10: PMID: 32230846
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PNU-282,987, 10 mg | sc-200187 | 10 mg | $170.00 | |||
PNU-282,987, 50 mg | sc-200187A | 50 mg | $576.00 |