HTR3 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I (GF 109203X) acts as a selective inhibitor of protein kinase C, influencing various intracellular signaling cascades. Its unique indole structure allows for specific interactions with the kinase domain, stabilizing the inactive conformation of the enzyme. This compound exhibits distinct kinetic properties, with a rapid onset of action and prolonged effects, modulating cellular responses through targeted inhibition of phosphorylation events. Its lipophilic nature enhances membrane permeability, facilitating cellular uptake. | ||||||
Tropisetron hydrochloride | 105826-92-4 | sc-204930 sc-204930A | 10 mg 50 mg | $96.00 $571.00 | 2 | |
Tropisetron hydrochloride functions as a potent antagonist of the 5-HT3 receptor, characterized by its ability to disrupt serotonin-mediated signaling pathways. The compound's unique structural features enable it to form specific hydrogen bonds and hydrophobic interactions with receptor sites, effectively blocking ion channel activation. Its rapid binding kinetics and high affinity contribute to its efficacy in modulating neurotransmitter release, influencing synaptic transmission dynamics. Additionally, its solubility profile enhances its distribution in biological systems. | ||||||
Metoclopramide | 364-62-5 | sc-358363 | 100 g | $465.00 | 1 | |
Metoclopramide acts as a selective antagonist at the 5-HT3 receptor, exhibiting unique binding characteristics that facilitate its interaction with the receptor's allosteric sites. This compound demonstrates a distinct ability to stabilize receptor conformation, thereby modulating downstream signaling pathways. Its kinetic profile reveals a rapid association and dissociation rate, allowing for dynamic regulation of neurotransmitter activity. Furthermore, its amphipathic nature enhances membrane permeability, influencing its bioavailability in various environments. | ||||||
PNU-282,987 | 123464-89-1 | sc-200187 sc-200187A | 10 mg 50 mg | $170.00 $576.00 | 3 | |
PNU-282,987 is a potent agonist at the 5-HT3 receptor, characterized by its high affinity for specific binding sites that induce conformational changes in the receptor. This compound uniquely engages in multiple molecular interactions, enhancing receptor activation and promoting distinct signaling cascades. Its reaction kinetics indicate a slower onset but prolonged effect, allowing for sustained modulation of receptor activity. Additionally, its lipophilic properties facilitate effective membrane integration, impacting its overall interaction dynamics. | ||||||