Pimozide is a D2DR inhibitor and antipsychotic which binds with very high affinity and inhibits SR-7 (Ki = 0.5 nM). Pimozide blocks establishment but not expression of amphetamine produced environment specific conditioning. Pimozide is a calcium channel protein inhibitor.
1. Roth, B.L., et al. 1994. J. Pharmacol. Exp. Ther. 268: 1403-1410. PMID: 7908055
Soluble in DMSO (100 mM), and chloroform (25 mg + 5 mL of CHCl3). Insoluble in water.
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