Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
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Serine proteinase inhibitors (serpins) function as regulators of serine proteinase activity in a variety of physiological processes. Proteinase inhibitor-9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a member of the Ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis, and is also an inhibitor of caspase-1 and, to a lesser extent, caspase-4 and caspase-8. Because granzyme B promotes DNA degradation and rapidly translocates to the nucleus to bind to a nuclear component, PI-9 is present in the nuclei of human cytotoxic cells, endothelial cells and epithelial cells. PI-9 is exported from nuclei via a leptomycin B-sensitive pathway, suggesting that the nucleocytoplasmic distribution of PI-9 involves a nonconventional nuclear import pathway and the export factor CRM1. Estrogen rapidly and strongly induces PI-9, which is an estrogen-regulated human gene. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B, particulary during target cell killling. In addition, PI-9 is expressed in a variety of human and murine tumors.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.