p-Stat3 Antibody (6D779): sc-71792

p-Stat3 Antibody (6D779) is a mouse monoclonal IgG1 antibody that detects p-Stat3 in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Stat3 is a critical component of the signal transducer and activator of transcription (Stat) family, which plays a vital role in mediating cellular responses to various cytokines and growth factors. As a member of the Stat family, p-Stat3 integrates extracellular signals into precise transcriptional responses that influence processes such as inflammation, immune regulation, and tissue repair. p-Stat3 acts downstream of receptors like gp130 and the epidermal growth factor receptor (EGFR), linking ligand binding to specific gene activation. Upon activation, Stat3 undergoes phosphorylation at specific tyrosine residues, which is essential for dimerization and subsequent translocation to the nucleus, where p-Stat3 regulates the expression of genes involved in cell proliferation, survival, and differentiation. p-Stat3 cooperates with other transcription factors to regulate a wide array of target genes, amplifying impact on diverse cellular pathways. This process is particularly important in cancer contexts, as aberrant Stat3 activation is often associated with tumorigenesis and poor prognosis. p-Stat3 (6D779) antibody specifically recognizes the phosphorylated form of Stat3, allowing researchers to investigate activation status in various biological contexts, including studies on immune responses and cancer biology. By utilizing anti-p-Stat3 antibody (6D779), scientists can gain insights into regulatory mechanisms of Stat3 and interactions with other signaling pathways, ultimately contributing to a better understanding of roles in health and disease.

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p-Stat3 Antibody (6D779) References:

1. Expression and clinical significance of STAT3, P-STAT3, and VEGF-C in small cell lung cancer.  |  Zhao, X., et al. 2012. Asian Pac J Cancer Prev. 13: 2873-7. PMID: 22938476
2. Expression and significance of leptin receptor, p-STAT3 and p-AKT in diffuse large B-cell lymphoma.  |  Lin, S., et al. 2014. Acta Histochem. 116: 126-30. PMID: 24054064
3. Prognostic Value and Clinicopathological Significance of p-stat3 Among Gastric Carcinoma Patients: A Systematic Review and Meta-Analysis.  |  Ji, K., et al. 2016. Medicine (Baltimore). 95: e2641. PMID: 26844481
4. The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis.  |  Ji, K., et al. 2016. PLoS One. 11: e0160125. PMID: 27504822
5. The decreased expression of Stat3 and p-Stat3 in preeclampsia-like rat placenta.  |  Zhang, Z., et al. 2018. J Mol Histol. 49: 175-183. PMID: 29353343
6. PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.  |  Wang, L., et al. 2018. Mol Cell Endocrinol. 474: 137-150. PMID: 29501586
7. Clinicopathological and Prognostic Role of STAT3/p-STAT3 in Breast Cancer Patients in China: A Meta-Analysis.  |  Li, Y., et al. 2019. Sci Rep. 9: 11243. PMID: 31375715
8. p-STAT3 expression in breast cancer correlates negatively with tumor size and HER2 status.  |  Wang, Y., et al. 2021. Medicine (Baltimore). 100: e25124. PMID: 33725911
9. Increased expression of the p-STAT3/IL-17 signaling pathway in patients with dermatomyositis.  |  Li, D., et al. 2023. Mod Rheumatol. 34: 129-136. PMID: 36478263
10. STAT3/p-STAT3 expression is correlated with clinicopathological characteristics and prognosis in non-small cell lung cancer.  |  Li, J., et al. 2024. Histol Histopathol. 18827. PMID: 39468938

The preferred p-Stat3 antibody is p-Stat3 Antibody (B-7): sc-8059.