p-Stat3 Antibody (23G5): sc-56747

p-Stat3 Antibody (23G5) is a mouse monoclonal IgG1 antibody that detects p-Stat3 in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Stat3 is a critical component of signaling pathways activated by various cytokines, particularly interleukin-6 (IL-6) and growth factors, which play a vital role in regulating immune responses, cell growth, and differentiation. This activation occurs in response to extracellular signals binding to receptors such as gp130 and Janus kinases (JAKs), which phosphorylate Stat3 at tyrosine 705. Once phosphorylated, p-Stat3 dimerizes and translocates to the nucleus to regulate target gene expression, including genes involved in cell survival, proliferation, and angiogenesis. Additionally, p-Stat3 is integral to the modulation of inflammatory responses, influencing the production of cytokines and acute-phase proteins. Dysregulation of p-Stat3 signaling has been linked not only to oncogenesis but also to autoimmune disorders and chronic inflammatory diseases, highlighting its wide-ranging impact on cellular function. Understanding the mechanisms governing p-Stat3 activation and inhibition is critical for elucidating its role in pathological and physiological processes. Anti-p-Stat3 antibody (23G5) provides researchers with a reliable tool for studying the dynamics of Stat3 activation and its downstream effects in various biological contexts, thereby contributing to a deeper understanding of its role in health and disease.

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p-Stat3 Antibody (23G5) References:

1. Prognostic significance of STAT3/phosphorylated-STAT3 in tumor: a meta-analysis of literatures.  |  Kong, H., et al. 2015. Int J Clin Exp Med. 8: 8525-39. PMID: 26309504
2. Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy.  |  Huang, TT., et al. 2017. Int J Mol Sci. 18: PMID: 28594363
3. Correlation between p-STAT3 overexpression and prognosis in lung cancer: A systematic review and meta-analysis.  |  Tong, M., et al. 2017. PLoS One. 12: e0182282. PMID: 28797050
4. Expression of enhancer of zeste homolog 2 (EZH2) protein in histiocytic and dendritic cell neoplasms with evidence for p-ERK1/2-related, but not MYC- or p-STAT3-related cell signaling.  |  Tian, X., et al. 2018. Mod Pathol. 31: 553-561. PMID: 29327713
5. The correlation between phosphorylated Histone H3 (PHH3) and p-STAT3 in Meningiomas.  |  Ozek, E., et al. 2019. Clin Neurol Neurosurg. 178: 46-50. PMID: 30710729
6. Role and mechanism of the p-JAK2/p-STAT3 signaling pathway in follicular development in PCOS rats.  |  Wang, H., et al. 2023. Gen Comp Endocrinol. 330: 114138. PMID: 36202220
7. Clinicopathological Significance of STAT3 and p-STAT3 among 91 Patients with Adenocarcinoma of the Esophagogastric Junction.  |  Ma, RJ., et al. 2022. Dis Markers. 2022: 9311684. PMID: 36225196
8. Tamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1α pathway.  |  Meng, T., et al. 2023. Int Immunopharmacol. 125: 110978. PMID: 37925944
9. Paradoxical role of phosphorylated STAT3 in normal fertility and the pathogenesis of adenomyosis and endometriosis†.  |  Xu, Y., et al. 2024. Biol Reprod. 110: 5-13. PMID: 37930185
10. Interleukin-17 alleviates erastin-induced alveolar bone loss by suppressing ferroptosis via interaction between NRF2 and p-STAT3.  |  Bao, J., et al. 2024. J Clin Periodontol. 51: 233-250. PMID: 37961757

The preferred p-Stat3 antibody is p-Stat3 Antibody (B-7): sc-8059.