mucolipin 1 Antibody (F-10): sc-398868
- mucolipin 1 Antibody (F-10) is a mouse monoclonal IgG1 κ mucolipin 1 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 106-180 mapping within an internal region of mucolipin 1 of human origin
- mucolipin 1 Antibody (F-10) is recommended for detection of mucolipin 1 of human origin by WB, IP, IF and ELISA
- Anti-mucolipin 1 Antibody (F-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for mucolipin 1 Antibody (F-10) for WB applications. These reagents are now offered in bundles with mucolipin 1 Antibody (F-10) (see ordering information below).
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mucolipin 1 Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects mucolipin 1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-mucolipin 1 antibody (F-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The gene encoding human mucolipin 1 is located on chromosome 19p13.3-p13.2, and mutations in this gene are linked to mucolipidosis type IV (MLIV), a rare autosomal recessive lysosomal storage disorder characterized by psychomotor retardation, retinal degeneration, corneal opacities, and strabismus. Mucolipin 1 is primarily localized to the plasma membrane and features six transmembrane domains, which are crucial for function as a cation channel. The structure of mucolipin 1 allows regulation of permeability to calcium, sodium, and potassium ions, with intracellular calcium concentration playing a significant role in activity. This regulation is vital for lysosomal exocytosis and the trafficking of late endosomes and lysosomes, highlighting the importance of mucolipin 1 in cellular homeostasis and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
mucolipin 1 Antibody (F-10) References:
- Identification of the gene causing mucolipidosis type IV. | Bargal, R., et al. 2000. Nat Genet. 26: 118-23. PMID: 10973263
- Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV. | Bassi, MT., et al. 2000. Am J Hum Genet. 67: 1110-20. PMID: 11013137
- Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel. | Sun, M., et al. 2000. Hum Mol Genet. 9: 2471-8. PMID: 11030752
- Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway. | LaPlante, JM., et al. 2002. FEBS Lett. 532: 183-7. PMID: 12459486
- Mucolipidosis IV: ocular, systemic, and ultrastructural findings. | Merin, S., et al. 1975. Invest Ophthalmol. 14: 437-48. PMID: 166049
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
mucolipin 1 Antibody (F-10) | sc-398868 | 200 µg/ml | $322.00 | |||
mucolipin 1 Antibody (F-10): m-IgG Fc BP-HRP Bundle | sc-530949 | 200 µg Ab; 10 µg BP | $361.00 | |||
mucolipin 1 Antibody (F-10): m-IgGκ BP-HRP Bundle | sc-524514 | 200 µg Ab, 40 µg BP | $361.00 | |||
mucolipin 1 Antibody (F-10): m-IgG1 BP-HRP Bundle | sc-544331 | 200 µg Ab; 20 µg BP | $361.00 | |||
mucolipin 1 Antibody (F-10) AC | sc-398868 AC | 500 µg/ml, 25% agarose | $424.00 | |||
mucolipin 1 Antibody (F-10) HRP | sc-398868 HRP | 200 µg/ml | $322.00 | |||
mucolipin 1 Antibody (F-10) FITC | sc-398868 FITC | 200 µg/ml | $336.00 | |||
mucolipin 1 Antibody (F-10) PE | sc-398868 PE | 200 µg/ml | $349.00 | |||
mucolipin 1 Antibody (F-10) Alexa Fluor® 488 | sc-398868 AF488 | 200 µg/ml | $364.00 | |||
mucolipin 1 Antibody (F-10) Alexa Fluor® 546 | sc-398868 AF546 | 200 µg/ml | $364.00 | |||
mucolipin 1 Antibody (F-10) Alexa Fluor® 594 | sc-398868 AF594 | 200 µg/ml | $364.00 | |||
mucolipin 1 Antibody (F-10) Alexa Fluor® 647 | sc-398868 AF647 | 200 µg/ml | $364.00 | |||
mucolipin 1 Antibody (F-10) Alexa Fluor® 680 | sc-398868 AF680 | 200 µg/ml | $364.00 | |||
mucolipin 1 Antibody (F-10) Alexa Fluor® 790 | sc-398868 AF790 | 200 µg/ml | $364.00 |