IκB-ε Antibody (D-7): sc-373958

IκB-ε Antibody (D-7) is a mouse monoclonal IgG1 antibody that detects IκB-ε in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IκB-ε plays a crucial role in the regulation of the NF-kB signaling pathway, which is essential for controlling immune responses, cell proliferation, and survival. IκB-ε is primarily located in the cytoplasm, where IκB-ε binds to the RelA and c-Rel subunits of NF-kB, preventing their translocation to the nucleus and thereby inhibiting the expression of target genes involved in inflammation and immune responses. Proper functioning of IκB-ε is vital, as dysregulation can lead to various diseases, including cancer and autoimmune disorders. IκB-ε undergoes post-translational modifications, such as phosphorylation, which can influence stability and interaction with NF-kB complexes, further emphasizing importance in cellular signaling. Anti-IκB-ε antibody (D-7) is an invaluable tool for researchers studying the intricate mechanisms of NF-kB regulation and its implications in health and disease.

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IκB-ε Antibody (D-7) References:

1. Constitutive nuclear translocation of NF-kappa B in B cells in the absence of I kappa B degradation.  |  Doerre, S. and Corley, RB. 1999. J Immunol. 163: 269-77. PMID: 10384125
2. Stimulation of Fc gamma R receptors induces monocyte chemoattractant protein-1 in the human monocytic cell line THP-1 by a mechanism involving I kappa B-alpha degradation and formation of p50/p65 NF-kappa B/Rel complexes.  |  Alonso, A., et al. 2000. Int Immunol. 12: 547-54. PMID: 10744656
3. Activation of NF-kappa B via the Ikappa B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells.  |  Denk, A., et al. 2001. J Biol Chem. 276: 28451-8. PMID: 11337506
4. Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase.  |  Weaver, DJ., et al. 2001. J Immunol. 167: 1461-8. PMID: 11466366
5. Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells.  |  Cahir-McFarland, ED., et al. 2004. J Virol. 78: 4108-19. PMID: 15047827
6. Differential effects of tumor necrosis factor-alpha and CD40L on NF-kappa B inhibitory proteins I kappa B alpha, beta and epsilon and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt lymphoma cells.  |  Laskov, R., et al. 2005. Eur Cytokine Netw. 16: 267-76. PMID: 16464740
7. Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells.  |  Clark, JM., et al. 2011. PLoS One. 6: e24504. PMID: 21915344
8. Nfkbie-deficiency leads to increased susceptibility to develop B-cell lymphoproliferative disorders in aged mice.  |  Della-Valle, V., et al. 2020. Blood Cancer J. 10: 38. PMID: 32170099
9. REGγ promotes mantle cell lymphoma cell apoptosis by downregulating NF-κB signaling.  |  Zeng, XX., et al. 2023. Transl Cancer Res. 12: 310-320. PMID: 36915576
10. Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program.  |  Vaidehi Narayanan, H., et al. 2024. Proc Natl Acad Sci U S A. 121: e2309686121. PMID: 39024115

The preferred IκB-ε antibody is IκB-ε Antibody (G-4): sc-7275.