Histone Deacetylase 10 (HDAC10) Antibody (F-4): sc-376121
- Histone Deacetylase 10 (HDAC10) Antibody (F-4) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 61-116 mapping near the N-terminal of HDAC10 of human origin
- recommended for detection of HDAC10 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Histone Deacetylase 10 (HDAC10) Antibody (F-4) for WB applications. These reagents are now offered in bundles with Histone Deacetylase 10 (HDAC10) Antibody (F-4) (see ordering information below).
HDAC10 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody designed to target human HDAC10, a critical enzyme within the histone deacetylase family involved in chromatin remodeling, transcriptional regulation, and cellular differentiation. anti-HDAC10 antibody (F-4) is raised against amino acids 61-116, mapping near the N-terminal region of HDAC10, ensuring precise recognition and high specificity in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HDAC10, also called HD10, is a member of the class II HDACs, characterized by its N-terminal Hda1p-related catalytic domain and a unique C-terminal leucine-rich domain, which are essential for deacetylase activity and protein-protein interactions, respectively. HDAC10 shuttles between the cytoplasm and nucleus in response to cellular signals, thereby regulating gene expression and participating in various cellular processes. Post-translational modifications of HDAC10, including phosphorylation and ubiquitination, play a crucial role in modulating enzymatic activity, stability, and subcellular localization. Phosphorylation can influence HDAC10′s ability to interact with other proteins and localization within the cell, while ubiquitination may target HDAC10 for proteasomal degradation, thereby regulating levels and activity within the cell. These modifications are vital for the dynamic regulation of HDAC10′s function in epigenetic control and involvement in cellular pathways related to cancer and neurodegenerative diseases. Understanding the post-translational modifications of HDAC10 is essential for elucidating disease mechanisms and developing targeted therapeutic strategies. HDAC10 (F-4) antibody enables researchers to effectively study the intricate regulation of HDAC10, including structural dynamics and post-translational modifications, advancing the understanding of chromatin biology and facilitating the discovery of novel treatments for various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Histone Deacetylase 10 (HDAC10) Antibody (F-4) | sc-376121 | 200 µg/ml | $322.00 | |||
Histone Deacetylase 10 (HDAC10) Antibody (F-4): m-IgG Fc BP-HRP Bundle | sc-540517 | 200 µg Ab; 10 µg BP | $361.00 | |||
Histone Deacetylase 10 (HDAC10) Antibody (F-4): m-IgG1 BP-HRP Bundle | sc-542176 | 200 µg Ab; 20 µg BP | $361.00 |