GHR Antibody (MAB 1): sc-69883

GHR Antibody (MAB 1) is a mouse monoclonal IgG1 antibody that detects growth hormone receptor (GHR) in human, ovine, and rabbit samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). GHR plays a crucial role in mediating the effects of growth hormone, which is essential for normal growth and metabolism. This integral membrane protein is a member of the cytokine receptor family and is primarily located on the surface of target cells, where GHR facilitates the binding of growth hormone, triggering a cascade of intracellular signaling pathways that promote growth and metabolic regulation. Notably, GHR exists in both membrane-bound and soluble forms, with the latter known as growth hormone-binding protein (GHBP), which is produced through proteolytic cleavage of the extracellular domain of GHR. The presence of GHBP is significant as reduced levels are linked to growth hormone insensitivity syndrome, highlighting GHR′s importance in maintaining normal physiological functions. GHR is transcribed from at least two different promoters, resulting in two isoforms, GHR 1A and GHR 1B, both of which are expressed in the liver, while GHR 1B is also found in muscle, uterus, and ovary tissues, indicating diverse roles in various biological processes. Anti-GHR antibody (MAB 1) is an invaluable tool for researchers studying growth hormone signaling and its implications in growth disorders and metabolic diseases.

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GHR Antibody (MAB 1) References:

1. Disulfide linkage of growth hormone (GH) receptors (GHR) reflects GH-induced GHR dimerization. Association of JAK2 with the GHR is enhanced by receptor dimerization.  |  Zhang, Y., et al. 1999. J Biol Chem. 274: 33072-84. PMID: 10551877
2. DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.  |  Liu, Z., et al. 2016. FASEB J. 30: 635-52. PMID: 26481310
3. Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons.  |  Cady, G., et al. 2017. Mol Metab. 6: 393-405. PMID: 28462074
4. Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer.  |  Yu, H., et al. 2018. J Transl Med. 16: 41. PMID: 29482569
5. Zinc ions increase GH signaling ability through regulation of available plasma membrane-localized GHR.  |  Li, R., et al. 2019. J Cell Physiol. 234: 23388-23397. PMID: 31173363
6. GHR gene transcript heterogeneity may explain phenotypic variability in GHR pseudoexon (6Ψ) patients.  |  Chatterjee, S., et al. 2020. Endocr Connect. 9: 211-22. PMID: 32061156
7. GHR and IGF2R genes may contribute to normal variations in craniofacial dimensions: Insights from an admixed population.  |  Marañón-Vásquez, GA., et al. 2020. Am J Orthod Dentofacial Orthop. 158: 722-730.e16. PMID: 33008707
8. Mild phenotype in two siblings with a missense GHR variant.  |  Sarıkaya Özdemir, B., et al. 2021. J Pediatr Endocrinol Metab. 34: 1349-1354. PMID: 34218547
9. Down-regulation of hepatic expression of GHR/STAT5/IGF-1 signaling pathway fosters development and aggressiveness of HCV-related hepatocellular carcinoma: Crosstalk with Snail-1 and type 2 transforming growth factor-beta receptor.  |  Abu El-Makarem, MA., et al. 2022. PLoS One. 17: e0277266. PMID: 36374927
10. Circular RNA circ_0022707 impedes the progression of preeclampsia via the miR-3135b/GHR/PI3K/Akt axis.  |  Shao, H., et al. 2024. Funct Integr Genomics. 24: 208. PMID: 39499344

The preferred GHR antibody is GHR Antibody (B-10): sc-137185.