Gelsolin Antibody (F-3): sc-271001
- Gelsolin Antibody (F-3) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 596-665 mapping near the C-terminus of Gelsolin of human origin
- recommended for detection of plasma and cytoplasmic Gelsolin of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Gelsolin Antibody (F-3). This work is in progress.
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Gelsolin Antibody (F-3) is a mouse monoclonal IgM antibody that detects Gelsolin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gelsolin plays a crucial role in regulating actin filament dynamics, which is essential for various cellular processes, including motility, shape maintenance, and intracellular transport. By severing actin filaments in the presence of calcium, Gelsolin facilitates cytoskeleton remodeling, allowing cells to adapt to changing environments and respond to external stimuli. This actin-severing activity is particularly important in leukocytes and platelets, where rapid changes in cell shape are necessary for immune responses and clot formation. Additionally, Gelsolin contributes to clearing actin from circulation, preventing potential toxicity associated with free actin in extracellular space, especially during cell necrosis. Gelsolin′s unique ability to function both intracellularly and extracellularly highlights Gelsolin′s significance in maintaining cellular integrity and homeostasis. Anti-Gelsolin antibody (F-3) serves as an invaluable tool for researchers studying actin dynamics and related cellular functions.
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Gelsolin Antibody (F-3) References:
- Multifunctional roles of gelsolin in health and diseases. | Li, GH., et al. 2012. Med Res Rev. 32: 999-1025. PMID: 22886630
- Potential therapeutic implications of gelsolin in Alzheimer's disease. | Ji, L., et al. 2015. J Alzheimers Dis. 44: 13-25. PMID: 25208622
- Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment. | Hsieh, CH. and Wang, YC. 2022. Kaohsiung J Med Sci. 38: 819-825. PMID: 35942641
- Gelsolin variant amyloidosis mimicking progressive bulbar palsy. | Park, J., et al. 2022. Muscle Nerve. 66: E28-E30. PMID: 36047766
- Loss of secreted gelsolin enhances response to anticancer therapies. | Lim, KHJ., et al. 2022. J Immunother Cancer. 10: PMID: 36162919
- Gelsolin as a Potential Clinical Biomarker in Psoriasis Vulgaris. | Lee, SH., et al. 2023. J Clin Med. 12: PMID: 36902587
- Role and therapeutic potential of gelsolin in atherosclerosis. | Zhang, Q., et al. 2023. J Mol Cell Cardiol. 178: 59-67. PMID: 36967105
- Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation. | Lee, J., et al. 2024. Cell Death Differ. 31: 1679-1694. PMID: 39179640
- Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD. | Sui, J., et al. 2024. JCI Insight. 9: PMID: 39352744
- Gelsolin regulates intestinal stem cell regeneration and Th17 cellular function. | Du, J., et al. 2024. Cell Commun Signal. 22: 524. PMID: 39472865
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gelsolin Antibody (F-3) | sc-271001 | 200 µg/ml | $322.00 |