E-cadherin Antibody (6F9): sc-52328
- E-cadherin Antibody (6F9) is a mouse monoclonal IgG1, cited in 13 publications, provided at 500 µl
- raised against affinity purified 80 kDa extracellular fragments of E-cadherin of A-431 vulva carcinoma cells of human origin
- recommended for detection of E-cadherin of mouse, rat and human origin by WB, IP and IF
- See E-cadherin (G-10): sc-8426 for E-cadherin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for E-cadherin Antibody (6F9). This work is in progress.
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SEE ALSO...
E-cadherin Antibody (6F9) is a mouse monoclonal IgG1 antibody that detects E-cadherin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). E-cadherin plays a crucial role in maintaining epithelial integrity and tissue architecture by facilitating cell-cell adhesion, which is essential for proper morphogenesis and the prevention of tumor metastasis. E-cadherin is primarily located at the cell membrane, where E-cadherin forms adherens junctions with neighboring cells, thereby contributing to the formation of tight epithelial layers. E-cadherin′s location at the membrane is critical, as dysfunction or loss is often associated with increased cellular motility and invasiveness, hallmark features of cancer progression. E-cadherin′s extracellular domain is characterized by a series of five homologous repeats that are vital for adhesive properties, while E-cadherin′s intracellular domain interacts with cytoplasmic proteins like β-catenin, linking to the actin cytoskeleton and influencing cellular signaling pathways. Anti-E-cadherin antibody (6F9) is an invaluable tool for researchers studying cell adhesion mechanisms, epithelial biology, and cancer metastasis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E-cadherin Antibody (6F9) | sc-52328 | 500 µl | $322.00 |