DP2 Antibody (BM16): sc-21798

DP2 Antibody (BM16) is a rat monoclonal IgG2a antibody that detects DP2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). DP2, also known as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), is a G protein-coupled receptor that plays a pivotal role in mediating prostaglandin D2 (PGD2) effects in various physiological and pathological processes. DP2 is predominantly located on specific types of white blood cells, including Th2 cells, eosinophils, and basophils, which are crucial for orchestrating immune responses. DP2 localization on these immune cells allows for targeted regulation of allergic and inflammatory responses, particularly in conditions such as asthma, allergic rhinitis, and atopic dermatitis. Upon PGD2 activation, DP2 initiates signaling events that promote Th2 cell chemotaxis, leading to production of key cytokines such as IL-4, IL-5, and IL-13, which are essential for Th2-type immune response development. DP2′s importance in immune regulation and inflammation highlights potential as a pharmacological target for therapeutic intervention in related disorders, making anti-DP2 antibody (BM16) an invaluable tool for studying these critical pathways.

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DP2 Antibody (BM16) References:

1. 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils.  |  Monneret, G., et al. 2003. J Pharmacol Exp Ther. 304: 349-55. PMID: 12490611
2. Emerging roles of DP and CRTH2 in allergic inflammation.  |  Kostenis, E. and Ulven, T. 2006. Trends Mol Med. 12: 148-58. PMID: 16545607
3. PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.  |  Schröder, R., et al. 2012. PLoS One. 7: e33329. PMID: 22442685
4. Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs.  |  Norman, P. 2014. Expert Opin Investig Drugs. 23: 55-66. PMID: 24073896
5. Expression of DP2 (CRTh2), a prostaglandin D₂ receptor, in human mast cells.  |  Moon, TC., et al. 2014. PLoS One. 9: e108595. PMID: 25268140
6. Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2.  |  Nagata, N., et al. 2017. PLoS One. 12: e0175452. PMID: 28394950
7. CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain.  |  Zuo, S., et al. 2018. EMBO Mol Med. 10: PMID: 29335338
8. CRTH2 Mediates Profibrotic Macrophage Differentiation and Promotes Lung Fibrosis.  |  Cao, Y., et al. 2022. Am J Respir Cell Mol Biol. 67: 201-214. PMID: 35585756
9. Over-expression of CRTH2 indicates eosinophilic inflammation and poor prognosis in recurrent nasal polyps.  |  Chen, W., et al. 2022. Front Immunol. 13: 1046426. PMID: 36466917
10. Vasoactive Intestinal Peptide Receptor, CRTH2, Antagonist Treatment Improves Eosinophil and Mast Cell-Mediated Esophageal Remodeling and Motility Dysfunction in Eosinophilic Esophagitis.  |  Yadavalli, CS., et al. 2024. Cells. 13: PMID: 38391908

The preferred DP2 antibody is DP2 Antibody (C-5): sc-271898.