Cytokeratin 5 Antibody (AE14): sc-80606
- Cytokeratin 5 Antibody (AE14) is a mouse monoclonal IgG2b κ, cited in 5 publications, provided at 200 µg/ml
- raised against hair keratins of human origin
- recommended for detection of Cytokeratin 5 of human and bovine origin by WB and IP; may cross-react with some acidic hair cytokeratins
- See Cytokeratin 5 (RCK103): sc-32721 for Cytokeratin 5 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Cytokeratin 5 Antibody (AE14) for WB applications. This reagent is now offered in a bundle with Cytokeratin 5 Antibody (AE14) (see ordering information below).
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Cytokeratin 5 Antibody (AE14) is a mouse monoclonal IgG2b antibody that detects Cytokeratin 5 in human and bovine samples through applications such as western blotting (WB) and immunoprecipitation (IP). Cytokeratin 5 is a vital component of the cytoskeletal structure in epithelial cells, primarily located in the basal layer of stratified epithelia, where Cytokeratin 5 plays a crucial role in maintaining cellular integrity and resilience against mechanical stress. This localization is particularly important as Cytokeratin 5 contributes to the overall stability of epithelial tissues, which are often subjected to physical abrasion and injury. Additionally, Cytokeratin 5 serves as a key marker for identifying basal cell types in various tissues, making anti-Cytokeratin 5 antibody (AE14) invaluable in the study of epithelial differentiation and the characterization of malignant tumors. Mutations in the gene encoding Cytokeratin 5 (KRT5) can lead to severe skin disorders such as epidermolysis bullosa, underscoring Cytokeratin 5′s significance in both health and disease. Cytokeratin 5 (AE14) antibody is therefore an essential tool for researchers investigating epithelial biology and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cytokeratin 5 Antibody (AE14) References:
- An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18 expression in breast papillomas and papillary carcinomas. | Wang, Y., et al. 2013. Diagn Pathol. 8: 8. PMID: 23327593
- Cytokeratin 5/6 and P63 immunophenotype of thyroid lymphoepithelial complexes. | Handra-Luca, A. and Dragoescu, E. 2016. Ann Diagn Pathol. 23: 58-61. PMID: 27130144
- Cytokeratin 5/6 expression, prognosis, and association with estrogen receptor α in high-grade serous ovarian carcinoma. | Taube, ET., et al. 2017. Hum Pathol. 67: 30-36. PMID: 28414091
- Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis. | Hashmi, AA., et al. 2018. BMC Res Notes. 11: 207. PMID: 29587848
- Biological significance of GATA3, cytokeratin 20, cytokeratin 5/6 and p53 expression in muscle-invasive bladder cancer. | Wang, CC., et al. 2019. PLoS One. 14: e0221785. PMID: 31469885
- Cytokeratin 5 alters β-catenin dynamics in breast cancer cells. | McGinn, O., et al. 2020. Oncogene. 39: 2478-2492. PMID: 31988452
- Correlation between salivary estrogen levels and oral epithelial cytokeratin 5 expression. | Handajani, J., et al. 2020. F1000Res. 9: 186. PMID: 32399205
- Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis. | Zhang, X., et al. 2021. Cell Death Dis. 12: 867. PMID: 34556631
- Utility of D2-40, Cytokeratin 5/6, and High-Molecular-weight Cytokeratin (Clone 34βE12) in Distinguishing Intraductal Spread of Urothelial Carcinoma From Prostatic Stromal Invasion. | Iakymenko, OA., et al. 2022. Am J Surg Pathol. 46: 454-463. PMID: 34560681
- Cytokeratin 5/6 expression in pT1 bladder cancer predicts intravesical recurrence in patients treated with bacillus Calmette-Guérin instillation. | Yamamoto, Y., et al. 2022. Pathology. 54: 700-706. PMID: 35527047
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 5 Antibody (AE14) | sc-80606 | 200 µg/ml | $322.00 | |||
Cytokeratin 5 Antibody (AE14): m-IgG Fc BP-HRP Bundle | sc-551974 | 200 µg Ab; 10 µg BP | $361.00 |