cyclin D3 Antibody (1): sc-135875
- cyclin D3 Antibody (1) is a mouse monoclonal IgG2b, cited in 4 publications, provided at 50 µg/0.5 ml
- raised against amino acids 127-292 of cyclin D3 of human origin
- recommended for detection of cyclin D3 of mouse, rat, human and canine origin by WB, IP and IF
- See cyclin D3 (D-7): sc-6283 for cyclin D3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for cyclin D3 Antibody (1). This work is in progress.
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Cyclin D3 Antibody (1) is a mouse monoclonal IgG2b antibody that detects cyclin D3 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cyclin D3 plays a pivotal role in cell cycle regulation, particularly during the G1 phase, where cyclin D3 is essential for the transition to the S phase. Cyclin D3 is crucial for the phosphorylation of the retinoblastoma protein, which in turn activates E2F transcription factors that drive the expression of genes necessary for DNA synthesis and cell proliferation. Proper functioning of cyclin D3 is vital for normal cell cycle progression, and dysregulation of cyclin D3 activity can lead to uncontrolled cell division, contributing to oncogenesis. Notably, cyclin D3 is part of a family of cyclins that includes cyclin D1 and cyclin D2, which also interact with cyclin-dependent kinases to regulate cell cycle transitions. The ability of cyclin D3 to modulate these processes underscores cyclin D3′s importance in both normal cellular function and the development of various cancers, making cyclin D3 a significant target for research and therapeutic interventions. Anti-cyclin D3 antibody (1) provides a reliable tool for studying the dynamics of cell cycle regulation and its implications in disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cyclin D3 Antibody (1) References:
- Cyclin D3 is essential for intestinal epithelial cell proliferation. | Ko, TC., et al. 2002. World J Surg. 26: 812-8. PMID: 11948368
- Cyclin D3 expression in primary Ta/T1 bladder cancer. | Lopez-Beltran, A., et al. 2006. J Pathol. 209: 106-13. PMID: 16482499
- Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor. | Zong, H., et al. 2007. Mol Cell Biol. 27: 7125-42. PMID: 17698582
- Cyclin D3 action in androgen receptor regulation and prostate cancer. | Olshavsky, NA., et al. 2008. Oncogene. 27: 3111-21. PMID: 18084330
- Cyclin D3/CDK11(p58) complex involved in Schwann cells proliferation repression caused by lipopolysaccharide. | Duan, Y., et al. 2010. Inflammation. 33: 189-99. PMID: 20066559
- Cyclin D3 is dispensable for human diffuse large B-cell lymphoma survival and growth: evidence for redundancy with cyclin E. | Gumina, MR., et al. 2010. Cell Cycle. 9: 820-8. PMID: 20107311
- Cyclin D1 and cyclin D3 show divergent responses to distinct mitogenic stimulation. | Anderson, AA., et al. 2010. J Cell Physiol. 225: 638-45. PMID: 20458731
- High cyclin D3 expression confers erlotinib resistance in aerodigestive tract cancer. | Petty, WJ., et al. 2011. Lung Cancer. 74: 384-91. PMID: 21555162
- Cyclin D3 sensitizes tumor cells to tumor necrosis factor-induced, c-Myc-dependent apoptosis. | Jänicke, RU., et al. 1996. Mol Cell Biol. 16: 5245-53. PMID: 8816437
- Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy. | Das, SK., et al. 1999. J Mol Endocrinol. 22: 91-101. PMID: 9924184
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin D3 Antibody (1) | sc-135875 | 50 µg/0.5 ml | $322.00 |