COL6A Antibody (3C4): sc-47712
- COL6A Antibody (3C4) is a mouse monoclonal IgG1 κ COL6A antibody, cited in 8 publications, provided at 200 µg/ml
- raised against purified Collagen VI of human origin
- COL6A Antibody (3C4) is recommended for detection of globular domains of collagen VI molecules of human origin by WB, IP, IF and IHC(P)
- Anti-COL6A Antibody (3C4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for COL6A Antibody (3C4). This work is in progress.
COL6A Antibody (3C4) is a mouse monoclonal IgG1 kappa light chain antibody that detects the COL6A protein of human origin by immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). COL6A (3C4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. COL6A protein is a crucial component of the extracellular matrix, primarily found in connective tissues, where COL6A plays a significant role in providing structural support and strength. COL6A belongs to the collagen family, characterized by a unique triple helix structure that allows for stable fibril formation. This structural integrity is vital for proper functioning of tissues such as tendons, cartilage, and skin, helping maintain elasticity and resilience under mechanical stress. COL6A interacts with other proteins in the extracellular matrix, contributing to cell adhesion and signaling pathways essential for tissue repair and regeneration. COL6A′s ability to form complexes with other collagens and matrix proteins underscores COL6A′s importance in maintaining normal tissue architecture and function, making COL6A a key target for research in various pathological conditions, including fibrosis and muscular dystrophies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
COL6A Antibody (3C4) References:
- Collagen and bone strength. | Boskey, AL., et al. 1999. J Bone Miner Res. 14: 330-5. PMID: 10027897
- Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways. | Alberio, L. and Dale, GL. 1999. Eur J Clin Invest. 29: 1066-76. PMID: 10583456
- Pathological characteristics of skeletal muscle in Ullrich's disease with collagen VI deficiency. | Higuchi, I., et al. 2003. Neuromuscul Disord. 13: 310-6. PMID: 12868500
- Collagen type VI expression during cardiac development and in human fetuses with trisomy 21. | Gittenberger-de Groot, AC., et al. 2003. Anat Rec A Discov Mol Cell Evol Biol. 275: 1109-16. PMID: 14613310
- Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency. | Irwin, WA., et al. 2003. Nat Genet. 35: 367-71. PMID: 14625552
- Modulation of collagen fibrillogenesis by tenascin-X and type VI collagen. | Minamitani, T., et al. 2004. Exp Cell Res. 298: 305-15. PMID: 15242785
- Cell adhesion to collagenous matrices. | McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
- Versatile collagens in invertebrates. | Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
- The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease. | Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COL6A Antibody (3C4) | sc-47712 | 200 µg/ml | $322.00 | |||
COL6A Antibody (3C4) AC | sc-47712 AC | 500 µg/ml, 25% agarose | $424.00 | |||
COL6A Antibody (3C4) HRP | sc-47712 HRP | 200 µg/ml | $322.00 | |||
COL6A Antibody (3C4) FITC | sc-47712 FITC | 200 µg/ml | $336.00 | |||
COL6A Antibody (3C4) PE | sc-47712 PE | 200 µg/ml | $349.00 | |||
COL6A Antibody (3C4) Alexa Fluor® 488 | sc-47712 AF488 | 200 µg/ml | $364.00 | |||
COL6A Antibody (3C4) Alexa Fluor® 546 | sc-47712 AF546 | 200 µg/ml | $364.00 | |||
COL6A Antibody (3C4) Alexa Fluor® 594 | sc-47712 AF594 | 200 µg/ml | $364.00 | |||
COL6A Antibody (3C4) Alexa Fluor® 647 | sc-47712 AF647 | 200 µg/ml | $364.00 | |||
COL6A Antibody (3C4) Alexa Fluor® 680 | sc-47712 AF680 | 200 µg/ml | $364.00 | |||
COL6A Antibody (3C4) Alexa Fluor® 790 | sc-47712 AF790 | 200 µg/ml | $364.00 |