COL6A Activators
COL6A Activators encompass a diverse array of chemical compounds that bolster the functionality of collagen type VI alpha chains through distinct biological and biochemical pathways. Ascorbic acid, critical for proline and lysine hydroxylation, ensures proper collagen triple helix formation, thus directly enhancing the structural integrity of COL6A fibers. Similarly, the presence of trace elements like Copper(II) sulfate and Manganese(II) chloride act as crucial cofactors, bolstering the enzymatic functions of lysyl oxidase and prolidase respectively, leading to increased cross-linking and proline recycling for COL6A synthesis. Compounds such as Beta-Aminopropionitrile and D-Penicillamine disrupt normal collagen cross-linking, inadvertently prompting an upsurge in COL6A synthesis to compensate for reduced structural stability.
Anthocyanidins with their antioxidant capabilities shield COL6A fibers from degradation, while Genistein's inhibition of tyrosinePhosphorylation may prevent aberrant fiber assembly, invoking a homeostatic increase in COL6A production. Lysophosphatidic Acid, by driving fibroblast proliferation and collagen synthesis, and Transforming Growth Factor Beta (TGF-β), a key regulatory cytokine in extracellular matrix production, notably enhance the deposition of COL6A in tissues. Retinoic Acid modulates gene expression to up-regulate extracellular matrix constituents including COL6A, thereby reinforcing tissue structure. Compounds like Calcium 2-oxoglutarate and Dimethyloxalylglycine interface with the prolyl hydroxylation process, essential for the maturation of COL6A fibers, with the latter stabilizing hypoxia-inducible factors to increase collagen synthesis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid is essential for the hydroxylation of proline and lysine residues in collagen, which is a critical post-translational modification for the stability and assembly of collagen triple helices. Enhanced hydroxylation by ascorbic acid directly increases the structural integrity of COL6A fibers. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper is a cofactor for lysyl oxidase, an enzyme responsible for the cross-linking of collagen fibers. Copper(II) sulfate supplementation enhances lysyl oxidase activity, leading to increased cross-linking and stabilization of COL6A fibers in the extracellular matrix. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese is a cofactor for prolidase, an enzyme involved in the recycling of proline for collagen synthesis. Manganese(II) chloride can enhance prolidase activity, leading to increased availability of proline for COL6A synthesis. | ||||||
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $104.00 | ||
Beta-Aminopropionitrile acts as an inhibitor of lysyl oxidase, which can lead to an increased synthesis of COL6A as a compensatory mechanism for reduced cross-linking of collagen fibers. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
D-Penicillamine can bind to aldehyde groups of lysine residues in collagen, preventing cross-linking and leading to an upregulation of COL6A synthesis to compensate for the decreased fiber stability. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can prevent the phosphorylation of collagen fibers, which may interfere with collagen fiber assembly and lead to an increased synthesis of COL6A to maintain extracellular matrix integrity. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Lysophosphatidic acid stimulates fibroblast proliferation and collagen synthesis via the LPA1 receptor, thereby increasing the production and integration of COL6A into the extracellular matrix. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates gene expression and can upregulate the synthesis of extracellular matrix proteins including COL6A, enhancing the structural components of tissues. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $84.00 $301.00 $374.00 $779.00 | 25 | |
Dimethyloxalylglycine inhibits prolyl hydroxylase domain-containing enzymes, leading to hypoxia-inducible factor stabilization and subsequent upregulation of collagen synthesis, including COL6A. | ||||||