CFTR Antibody (GA1): sc-20074
- CFTR Antibody (GA1) is a mouse monoclonal IgG1, cited in 2 publications, provided at 200 µg/ml
- raised against C-terminal recombinant human CFTR protein, corresponding to amino acids 1387-1480, requires amino acids 1445-1460
- recommended for detection of CFTR of human origin by WB, IP, IF and IHC(P)
- See CFTR (A-3): sc-376683 for CFTR antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CFTR Antibody (GA1). This work is in progress.
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SEE ALSO...
CFTR Antibody (GA1) is a mouse monoclonal IgG1 antibody that detects cystic fibrosis transmembrane conductance regulator (CFTR) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. CFTR plays a crucial role as a chloride channel in epithelial cells, primarily located in the apical membrane of airway, intestinal, and pancreatic cells, where CFTR regulates the movement of chloride ions and water across cell membranes. This function is vital for maintaining proper mucus viscosity, essential for effective mucociliary clearance in the respiratory system. Dysfunctional CFTR due to mutations leads to thick, sticky mucus accumulation, resulting in severe respiratory and digestive issues characteristic of cystic fibrosis. CFTR′s location in the cell directly influences epithelial surface hydration, impacting respiratory health, digestive, and reproductive functions. Anti-CFTR antibody (GA1) serves as an invaluable tool for researchers studying cystic fibrosis and related disorders, providing insights into underlying molecular mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CFTR Antibody (GA1) References:
- Transcriptional regulation of CFTR gene expression. | Gillen, AE. and Harris, A. 2012. Front Biosci (Elite Ed). 4: 587-92. PMID: 22201896
- CFTR activity and mitochondrial function. | Valdivieso, AG. and Santa-Coloma, TA. 2013. Redox Biol. 1: 190-202. PMID: 24024153
- Role of CFTR in epithelial physiology. | Saint-Criq, V. and Gray, MA. 2017. Cell Mol Life Sci. 74: 93-115. PMID: 27714410
- CFTR and TNR-CFTR expression and function in the kidney. | Souza-Menezes, J., et al. 2014. Biophys Rev. 6: 227-236. PMID: 28510183
- CFTR Modulator Therapy for Cystic Fibrosis. | Grasemann, H. 2017. N Engl J Med. 377: 2085-2088. PMID: 29099349
- Genetics of CFTR and male infertility. | Bieniek, JM., et al. 2021. Transl Androl Urol. 10: 1391-1400. PMID: 33850775
- CFTR, Cell Junctions and the Cytoskeleton. | Pankonien, I., et al. 2022. Int J Mol Sci. 23: PMID: 35269829
- Recovery of ΔF508-CFTR Function by Citrate. | Borkenhagen, B. and Prehm, P. 2022. Nutrients. 14: PMID: 36296967
- Structural basis for CFTR inhibition by CFTRinh-172. | Young, PG., et al. 2024. Proc Natl Acad Sci U S A. 121: e2316675121. PMID: 38422021
- CFTR function is impaired in a subset of patients with pancreatitis carrying rare CFTR variants. | Angyal, D., et al. 2024. Pancreatology. 24: 394-403. PMID: 38493004
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CFTR Antibody (GA1) | sc-20074 | 200 µg/ml | $322.00 |