CD74 Antibody (A-6): sc-166047
- CD74 Antibody (A-6) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 17-296 mapping at the C-terminus of CD74 of human origin
- recommended for detection of CD74 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See CD74 (LN-2): sc-6262 for CD74 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG1 BP-HRP is the preferred secondary detection reagent for CD74 Antibody (A-6) for WB and IHC(P) applications. This reagent is now offered in a bundle with CD74 Antibody (A-6) (see ordering information below).
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CD74 Antibody (A-6) is a mouse monoclonal IgG1 antibody that detects CD74 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD74, also known as the invariant chain, plays a crucial role in the immune system by regulating the loading of peptides onto major histocompatibility complex class II (MHC II) molecules, which are essential for presenting antigens to T lymphocytes. This process is vital for initiating adaptive immune responses, as CD74 allows the immune system to recognize and respond to pathogens effectively. CD74 is predominantly expressed in B lymphocytes and is also found in a subset of T lymphocytes, highlighting CD74′s importance in both humoral and cellular immunity. CD74 expression on these immune cells not only facilitates the proper functioning of MHC II but also serves as a marker for certain immune cell populations, making anti-CD74 antibody (A-6) an invaluable tool for researchers studying immune responses and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD74 Antibody (A-6) References:
- CD74 induces TAp63 expression leading to B-cell survival. | Lantner, F., et al. 2007. Blood. 110: 4303-11. PMID: 17846227
- A CD74-dependent MHC class I endolysosomal cross-presentation pathway. | Basha, G., et al. 2012. Nat Immunol. 13: 237-45. PMID: 22306692
- Cell Surface CD74-MIF Interactions Drive Melanoma Survival in Response to Interferon-γ. | Tanese, K., et al. 2015. J Invest Dermatol. 135: 2775-2784. PMID: 26039541
- CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells. | Liu, Z., et al. 2016. Oncotarget. 7: 68303-68313. PMID: 27626171
- Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. | Pantouris, G., et al. 2018. Angew Chem Int Ed Engl. 57: 7116-7119. PMID: 29669180
- TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells. | Valiño-Rivas, L., et al. 2018. PLoS One. 13: e0199391. PMID: 29924850
- LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML. | Ruvolo, PP., et al. 2019. EBioMedicine. 44: 126-137. PMID: 31105032
- Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro. | Li, JQ., et al. 2022. Stem Cells Int. 2022: 4363632. PMID: 35069747
- Roles of LINC01473 and CD74 in osteoblasts in multiple myeloma bone disease. | Peng, F., et al. 2022. J Investig Med. 70: 1301-1307. PMID: 35145037
- Exploring the Role of CD74 and D-Dopachrome Tautomerase in COVID-19: Insights from Transcriptomic and Serum Analyses. | Ralchev Ralchev, N., et al. 2023. J Clin Med. 12: PMID: 37568438
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD74 Antibody (A-6) | sc-166047 | 200 µg/ml | $322.00 | |||
CD74 Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-542656 | 200 µg Ab; 20 µg BP | $361.00 |