CD7 Antibody (E-12): sc-48409

CD7 Antibody (E-12) is a mouse monoclonal IgG2b antibody that detects CD7 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD7 is a type I transmembrane glycoprotein that plays a crucial role in the immune system, particularly in T cell activation and differentiation. CD7 (E-12) monoclonal antibody recognizes protein expression on pluripotential hematopoietic cells, most human thymocytes, and a subset of peripheral blood T cells, making CD7 a significant marker for various hematological malignancies, including pluripotential stem cell leukemias and T cell acute lymphocytic leukemia. CD7′s importance extends to T cell receptor signaling, where CD7 aids in the activation of T cells with gamma/delta receptors, thereby influencing immune responses. Notably, CD7 expression is down-regulated in CD8 T cells from patients infected with HIV-1, highlighting CD7′s potential role in immune evasion and disease progression. Furthermore, CD7 is among the pan-T-cell antigens that are down-regulated during acute infectious mononucleosis, indicating CD7′s relevance in both normal and pathological immune responses. Anti-CD7 antibody (E-12) is an essential tool for researchers studying T cell biology and related diseases, providing insights into the mechanisms of T cell activation and the implications of CD7 in various immunological contexts.

The preferred CD7 antibody is CD7 Antibody (CBC.37): sc-59108.