CD7 Activators
CD7 Activators like A23187, Ionomycin, Forskolin, and IBMX predominantly operate by modulating intracellular calcium or cyclic AMP (cAMP) levels. Since CD7 is implicated in T cell activation, which relies heavily on calcium and cAMP signalling, these chemicals can enhance CD7 activity. Specifically, A23187 and Ionomycin increase intracellular calcium levels, thereby enhancing calcium-dependent signalling pathways that culminate in T cell activation, and thus, CD7 functional enhancement. Forskolin and IBMX, on the other hand, amplify cAMP levels, promoting T cell activation and indirectly enhancing CD7 activity.
Another significant class of CD7 activators includes Phorbol 12-myristate 13-acetate (PMA), Bryostatin 1, and Sanguinarine. These chemicals function as potent activators of protein kinase C (PKC), a kinase known to phosphorylate and activate CD7. By activating PKC, these compounds can directly enhance CD7 activity. Yet another group of CD7 activators, Okadaic Acid, ZAP-70 Inhibitor, Cyclosporin A, Prostaglandin E2, and Staurospsporine, exert their influence by affecting other proteins in T cell activation pathways. Okadaic Acid enhances CD7 activity by inhibiting protein phosphatases PP1 and PP2A, leading to increased protein phosphorylation, including the phosphorylation of CD7. ZAP-70 Inhibitor and Cyclosporin A enhance CD7 activity by inhibiting key proteins in T cell receptor signaling, thereby increasing the reliance on CD7 for T cell activation. Prostaglandin E2 enhances CD7 activity by activating the EP2/EP4 receptor, leading to increased intracellular cAMP levels which promote T cell activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a mobile ion carrier that forms complexes with divalent cations, especially calcium, and transports these ions through the cell membrane. Increased cytosolic calcium can lead to enhanced CD7 activity as it is involved in T cell activation which relies on calcium signalling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which is known to phosphorylate and activate CD7. By activating PKC, PMA can directly enhance CD7 activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Enhanced calcium signaling can lead to increased CD7 activity, as CD7 is involved in T cell activation which relies on calcium signalling. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 is a potent activator of protein kinase C (PKC), which is known to phosphorylate and activate CD7. By activating PKC, Bryostatin 1 can directly enhance CD7 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, which increases cyclic AMP (cAMP) levels. Elevated cAMP can enhance CD7 activity by promoting T cell activation, a process in which CD7 is directly involved. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that increases intracellular cAMP levels. Elevated cAMP promotes T cell activation, and thereby enhances CD7 activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased protein phosphorylation. Increased phosphorylation can enhance CD7 activity, as CD7 is known to be activated by phosphorylation. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Sanguinarine is a potent activator of protein kinase C (PKC), which is known to phosphorylate and activate CD7. By activating PKC, Sanguinarine can directly enhance CD7 activity. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressant that inhibits calcineurin, a phosphatase that dephosphorylates NFAT, a key transcription factor in T cell activation. Inhibition of calcineurin can increase reliance on CD7 for T cell activation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 can enhance CD7 activity by activating the EP2/EP4 receptor, leading to increased intracellular cAMP levels which promote T cell activation, and thereby enhances CD7 activity. | ||||||