CD40 Antibody (MAB89): sc-59047
- CD40 Antibody (MAB89) is a mouse monoclonal IgG1, cited in 3 publications, provided at 100 µg/ml
- raised against anti-IgM activated tonsillar B cells of human origin
- recommended for detection of CD40 of human origin by FCM
- See CD40 (H-10): sc-13128 for CD40 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD40 Antibody (MAB89). This work is in progress.
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CD40 Antibody (MAB89) is a mouse monoclonal IgG1 antibody that detects CD40 in human samples through flow cytometry (FCM). CD40 is a crucial co-stimulatory molecule found on the surface of B cells, playing a vital role in the activation and proliferation of these immune cells in response to signals from activated T helper cells. The interaction between CD40 and CD40L, expressed on T cells, is essential for initiating a cascade of intracellular signaling that leads to B cell activation, immunoglobulin class switching, and the production of antibodies, including IgE. This process is particularly important for the adaptive immune response, as CD40 enables B cells to produce high-affinity antibodies tailored to specific pathogens. Furthermore, CD40 signaling is intricately linked to various post-translational modifications, such as ubiquitination, which can influence CD40 stability and activity, thereby modulating the immune response. Anti-CD40 antibody (MAB89) is an invaluable tool for researchers studying B cell activation, immune responses, and the underlying mechanisms of various immunological disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD40 Antibody (MAB89) | sc-59047 | 100 µg/ml | $322.00 |