CD39L2 Antibody (SS05): sc-81994

CD39L2 Antibody (SS05) is a mouse monoclonal IgG2a kappa light chain antibody that detects the CD39L2 protein of human origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-CD39L2 antibody (SS05) is available as a non-conjugated format. CD39L2, also known as ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6), is a 484 amino acid integral membrane glycoprotein that plays a crucial role in nucleotide metabolism by hydrolyzing extracellular nucleotides, which is essential for regulating purinergic signaling pathways. CD39L2 (SS05) antibody targets a protein predominantly localized to the membrane of the Golgi apparatus, where CD39L2 is believed to facilitate glycosylation reactions, thereby influencing protein maturation and function. CD39L2 is expressed ubiquitously, with the highest levels found in heart tissue, and CD39L2 activity is modulated by calcium and magnesium ions, which are vital for enzymatic function. Multiple isoforms of CD39L2, resulting from alternative splicing, suggests a complex regulatory mechanism that may allow for diverse functional roles in various cellular contexts.

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CD39L2 Antibody (SS05) References:

1. Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2).  |  Hicks-Berger, CA., et al. 2000. J Biol Chem. 275: 34041-5. PMID: 10948193
2. CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart.  |  Yeung, G., et al. 2000. Biochemistry. 39: 12916-23. PMID: 11041856
3. Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function.  |  Ivanenkov, VV., et al. 2003. Biochemistry. 42: 11726-35. PMID: 14529283
4. E-NTPDases and ecto-5'-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings.  |  Rücker, B., et al. 2008. Life Sci. 82: 477-86. PMID: 18201730
5. cDNA cloning and chromosomal mapping of a mouse gene with homology to NTPases.  |  Chadwick, BP., et al. 1998. Mamm Genome. 9: 162-4. PMID: 9457681
6. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.  |  Chadwick, BP. and Frischauf, AM. 1998. Genomics. 50: 357-67. PMID: 9676430