Activated C3 Antibody (I3/15): sc-47687
- Activated C3 Antibody (I3/15) is a mouse monoclonal IgG1 κ Activated C3 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against complement protein factor C3dg of human origin
- recommended for detection of the precursor proteins C3b and iC3b as well as C3dg and the 105 kDa fragment of C3b (designated C3α) of human origin by WB and IP; non cross-reactive with C3a and C3β
- See C3 (B-9): sc-28294 for Activated C3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Activated C3 Antibody (I3/15) for WB applications. These reagents are now offered in bundles with Activated C3 Antibody (I3/15) (see ordering information below).
Activated C3 Antibody (I3/15) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Activated C3 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Activated C3 antibody (I3/15) is available as the non-conjugated form. Activated C3 protein plays a crucial role in the complement system, which is essential for immune defense against pathogens. Upon activation, C3 is cleaved into C3a and C3b, with C3a acting as an anaphylatoxin that promotes inflammation and C3b serving as an opsonin that enhances phagocytosis. Activated C3 (I3/15) antibody helps researchers study C3′s ability to initiate a cascade of immune responses, including recruitment of immune cells to infection sites and enhancement of antibody-mediated pathogen clearance. C3a interaction with C3aR and C3b binding to complement receptors on immune cells orchestrates an effective immune response. Dysregulation of C3 activation can lead to various pathological conditions, including autoimmune diseases and chronic inflammatory disorders, making Activated C3 (I3/15) monoclonal antibody critical for understanding immune system function and developing therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Activated C3 Antibody (I3/15) References:
- Receptors for activated C3 on thymus-dependent (T) lymphocytes of normal guinea-pigs. | Wilson, AB., et al. 1979. Immunology. 37: 377-84. PMID: 112046
- Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. | Mizuno, M., et al. 2004. Biol Reprod. 71: 1374-83. PMID: 15215199
- Degradation of aggregates of activated C3 (C3b) by monocytes of patients with rheumatoid arthritis is related to vasculitis. | Heurkens, AH., et al. 1990. Clin Exp Immunol. 80: 177-80. PMID: 2141558
- Direct quantitation of activated C3 in human plasma with monoclonal anti-iC3b-C3d-neoantigen. | Kanayama, Y., et al. 1986. J Immunol Methods. 88: 33-6. PMID: 2420896
- Identification of a nonproteolytically activated C3 with CR 1-binding properties in sera from subjects with primary biliary cirrhosis. | Nilsson, B., et al. 1986. Int Arch Allergy Appl Immunol. 80: 312-9. PMID: 3721599
- Contribution of activated C3 to lymphocyte-mediated cytolysis. | Klein, E., et al. 1986. Mol Immunol. 23: 1257-62. PMID: 3821739
- Contribution of activated C3 to lymphocyte-mediated target lysis: complement-dependent cellular cytotoxicity. | Yefenof, E., et al. 1984. Mol Immunol. 21: 1211-4. PMID: 6521746
- The binding of activated C3 to polysaccharides and immunoglobulins. | Capel, PJ., et al. 1978. J Immunol. 121: 2566-72. PMID: 722084
- A receptor for activated C3 in the human renal glomerular capillary wall. | Gelfand, MC., et al. 1975. Proc Clin Dial Transplant Forum. 5: 102-5. PMID: 785451
- Activated C3 (C3b) in the nephritic glomerulus. | Pan, C., et al. 1993. Pediatr Nephrol. 7: 379-86. PMID: 8398646
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Activated C3 Antibody (I3/15) | sc-47687 | 200 µg/ml | $322.00 | |||
Activated C3 Antibody (I3/15): m-IgG Fc BP-HRP Bundle | sc-536798 | 200 µg Ab; 10 µg BP | $361.00 | |||
Activated C3 Antibody (I3/15): m-IgGκ BP-HRP Bundle | sc-533962 | 200 µg Ab; 40 µg BP | $361.00 | |||
Activated C3 Antibody (I3/15): m-IgG1 BP-HRP Bundle | sc-544824 | 200 µg Ab; 20 µg BP | $361.00 |