Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (170): sc-65795

AChRβ1 Antibody (170) is a rat monoclonal IgG2a light chain antibody that detects AChRβ1 in mouse, rat, human, and Torpedo species by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AChRβ1, also known as CHRNB, CMS1D, CMS2A, SCCMS, or CHRNB1, is a 501 amino acid protein that plays a crucial role in the function of nicotinic acetylcholine receptors, which are essential for neurotransmission at the neuromuscular junction. These receptors are composed of five homologous subunits that form a transmembrane aqueous pore, allowing ions to flow in response to acetylcholine binding. The proper functioning of AChRβ1 is vital for muscle contraction and overall neuromuscular function, as defects in the gene encoding this protein can lead to congenital myasthenic syndrome slow-channel type (SCCMS), a condition characterized by muscle weakness affecting various muscle groups, including those responsible for eye movement and facial expressions. The ability of AChRβ1 to undergo conformational changes upon neurotransmitter binding is critical for its role in synaptic transmission, making AChRβ1 a significant target for research in neuromuscular disorders. Anti-AChRβ1 antibody (170) is an invaluable tool for studying the dynamics of this protein and its implications in health and disease.

The preferred Nicotinic Acetylcholine Receptor beta 1/CHRNB1 antibody is Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148): sc-65813.