RASSF8 Activators
RASSF8 Activators are a meticulously curated set of chemical compounds that influence various signaling pathways, indirectly amplifying the functional activity of RASSF8. Compounds like Forskolin and Dibutyryl-cAMP function by elevating cAMP levels, which sequentially activate PKA, a kinase that can phosphorylate proteins to modulate their activity, thereby possibly affecting the functional state of RASSF8 in cell cycle regulation. Similarly, LY294002, as a PI3K inhibitor, and Rapamycin, an mTOR inhibitor, alter their respective pathways, potentially tipping the signaling scales to enhance the RASSF8-mediated processes, pivotal for cell proliferation and apoptosis. Moreover, Thapsigargin's action in raising intracellular calcium levels could activate calcium-dependent signaling cascades, intersecting with RASSF8's role in cellular adhesion.
On another front, the histone deacetylase inhibitory action of Trichostatin A leads to altered gene expression, which could upregulate proteins that operate synergistically with RASSF8, reinforcing its involvement in cellular adhesion and migration. PD98059 and U0126 specifically target the MEK enzymes within the MAPK pathway, a pathway that can impact RASSF8's involvement in cell cycle control and apoptosis. Additionally, Sphingosine-1-phosphate and Y-27632 modulate cytoskeletal dynamics and cell contraction, respectively, which are processes that can engage RASSF8 in the regulation of cell morphology and motility. Lastly, Zoledronic Acid, by inhibiting farnesyl pyrophosphate synthase, may affect the post-translational modification of proteins within the RASSF8 pathway, potentially enhancing RASSF8's tumor suppressor activities. Collectively, these activators exert their biochemical prowess through indirect yet specific pathways, culminating in the elevated functional activity of RASSF8 without altering its expression levels directly.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which in turn can activate PKA. PKA phosphorylation can lead to the activation of RASSF8 by altering its interaction with other proteins and potentially promoting its role in cell cycle regulation and apoptosis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Histone deacetylase inhibitor that changes chromatin structure and gene expression. This can indirectly enhance RASSF8 activity by increasing the transcription of genes that are involved in the same pathways as RASSF8, specifically those related to cell adhesion and motility. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid modulates gene expression through retinoic acid receptors. By affecting gene expression, it can lead to the upregulation of proteins that are known to interact with RASSF8, thereby enhancing RASSF8's role in cell signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that indirectly influences RASSF8 by modulating the PI3K/AKT pathway, potentially shifting the balance towards pathways that RASSF8 is involved in, such as Hippo signaling, which is key for cell proliferation and apoptosis. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor that may lead to the enhancement of RASSF8 function by altering the MAPK/ERK pathway, which can have downstream effects on cell cycle and apoptosis pathways that RASSF8 is part of. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that can indirectly activate RASSF8 by inhibiting the mTOR pathway, which is known to interact with the pathways involving RASSF8, potentially affecting cell growth and proliferation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
A bioactive lipid that can activate signaling pathways involved in cytoskeletal rearrangement. By modulating these pathways, S1P may indirectly enhance RASSF8 activity related to cell migration and adhesion. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor that potentially enhances RASSF8 activity through the relaxation of the actin cytoskeleton, influencing cellular processes like migration that RASSF8 is implicated in. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
SERCA pump inhibitor that raises intracellular calcium levels, potentially activating pathways that could engage RASSF8 in processes such as cell adhesion and apoptosis. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
cAMP analog that activates PKA and can enhance RASSF8 activity by mimicking the effects of elevated cAMP, thereby influencing RASSF8's role in signaling pathways that regulate cell cycle and apoptosis. | ||||||