Date published: 2026-6-4

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N-SMase Antibodies

Santa Cruz Biotechnology features a diverse variety of N-SMase monoclonal antibodies for advanced research in cell signaling and lipid metabolism. N-SMase Antibodies are compatible with multiple techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). N-SMase, or neutral sphingomyelinase, plays a critical role in the hydrolysis of sphingomyelin to generate ceramide, a key lipid mediator involved in numerous cellular processes such as apoptosis, cell growth, and inflammation. Understanding the function of N-SMase is essential for elucidating its contributions to various diseases, including cancer and neurodegenerative disorders. The study of N-SMase and its pathways can provide insights into potential therapeutic targets and strategies. Research focused on N-SMase has revealed its significance in cellular stress responses and membrane organization. N-SMase activity has been linked to the regulation of exosome formation and intercellular communication. Investigating N-SMase mechanisms has enhanced our understanding of lipid-mediated signaling pathways. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing scientific knowledge of sphingolipid metabolism and its impact on human health.

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N-SMase Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

N-SMase Antibody (B-1)

sc-377135mouse IgG2a κ383-421 (m)WB, IP, IF, IHC(P), ELISAm
1
(3)

N-SMase Antibody (56-7)

sc-100593mouse IgG3 κ1-424 (h)WB, IP, IF, IHC(P), ELISAh
1
(2)

N-SMase2 Antibody (G-6)

sc-166637mouse IgG2a κ461-655 (h)WB, IP, IF, IHC(P), ELISAm, r, h
33
(10)

N-SMase CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

N-SMase Double Nickase Plasmid (h)

sc-405568-NIChGene KnockoutPuromycin0
(0)

N-SMase Double Nickase Plasmid (h2)

sc-405568-NIC-2hGene KnockoutPuromycin0
(0)

N-SMase CRISPR/Cas9 KO Plasmid (m)

sc-423034mGene KnockoutGFP0
(0)

N-SMase HDR Plasmid (m)

sc-423034-HDRmHomology Directed RepairPuromycin0
(0)

N-SMase2 CRISPR/Cas9 KO Plasmid (h)

sc-401937hGene KnockoutGFP
2
(0)

N-SMase2 HDR Plasmid (h)

sc-401937-HDRhHomology Directed RepairPuromycin
2
(0)

N-SMase2 Double Nickase Plasmid (h)

sc-401937-NIChGene KnockoutPuromycin
2
(0)

N-SMase2 Double Nickase Plasmid (h2)

sc-401937-NIC-2hGene KnockoutPuromycin
2
(0)

N-SMase2 CRISPR/Cas9 KO Plasmid (m)

sc-425544mGene KnockoutGFP
1
(0)

N-SMase2 HDR Plasmid (m)

sc-425544-HDRmHomology Directed RepairPuromycin
1
(0)

N-SMase CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

N-SMase2 CRISPR Activation Plasmid (h)

sc-401937-ACThGene ActivationPuro, Blast, Hygro
2
(0)

N-SMase siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

N-SMase siRNA (h)

sc-106277hGene SilencingN/A
3
(0)

N-SMase shRNA Plasmid (h)

sc-106277-SHhGene SilencingPuromycin
3
(0)

N-SMase shRNA (h) Lentiviral Particles

sc-106277-VhGene SilencingPuromycin
3
(0)

N-SMase siRNA (m)

sc-43574mGene SilencingN/A0
(0)

N-SMase shRNA Plasmid (m)

sc-43574-SHmGene SilencingPuromycin0
(0)

N-SMase shRNA (m) Lentiviral Particles

sc-43574-VmGene SilencingPuromycin0
(0)

N-SMase2 siRNA (h)

sc-62655hGene SilencingN/A
3
(0)

N-SMase2 shRNA Plasmid (h)

sc-62655-SHhGene SilencingPuromycin
3
(0)

N-SMase2 shRNA (h) Lentiviral Particles

sc-62655-VhGene SilencingPuromycin
3
(0)

N-SMase2 siRNA (m)

sc-62656mGene SilencingN/A
3
(0)

N-SMase2 shRNA Plasmid (m)

sc-62656-SHmGene SilencingPuromycin
3
(0)

N-SMase2 shRNA (m) Lentiviral Particles

sc-62656-VmGene SilencingPuromycin
3
(0)

N-SMase3 siRNA (h)

sc-95034hGene SilencingN/A0
(0)

N-SMase3 shRNA Plasmid (h)

sc-95034-SHhGene SilencingPuromycin0
(0)

N-SMase3 shRNA (h) Lentiviral Particles

sc-95034-VhGene SilencingPuromycin0
(0)

N-SMase3 siRNA (m)

sc-149774mGene SilencingN/A0
(0)

N-SMase3 shRNA Plasmid (m)

sc-149774-SHmGene SilencingPuromycin0
(0)

N-SMase3 shRNA (m) Lentiviral Particles

sc-149774-VmGene SilencingPuromycin0
(0)