Date published: 2025-10-30

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Kizuna_Plk1s1 Ativadores

The kizuna centrosomal protein, known by the gene symbol KIZ or C2orf39, is an important protein associated with the centrosome in cells. The centrosome is a key cellular structure that plays a crucial role in organizing microtubules and is critical for the process of cell division (mitosis). Kizuna is particularly vital during the mitotic phase, where it helps maintain the integrity of the centrosome and ensures proper mitotic spindle formation.This protein was dubbed "kizuna" because the term means "bonds" in Japanese, reflecting its function in maintaining the cohesive structure of the centrosome during the stressful conditions of cell division. Just as kizuna signifies strong social bonds or ties between people, the kizuna protein helps maintain the structural cohesion between centrioles, the cylindrical structures that comprise the centrosome.

Mutations or dysfunctions in the KIZ gene or the kizuna protein can lead to errors in cell division, which may have implications for various diseases, including cancer, where cell division becomes unregulated. Additionally, proper centrosomal function is crucial for the development and maintenance of organismal complexity, so alterations in proteins like kizuna can have significant developmental consequences.Kizuna's role extends beyond simply holding the centrosome together; it is also involved in the recruitment of other proteins to the centrosome and can influence the timing of cell cycle progression.

VEJA TAMBÉM

Nome do ProdutoCAS #Numero de CatalogoQuantidadePrecoUso e aplicacaoNOTAS

BI6727

755038-65-4sc-364432
sc-364432A
sc-364432B
sc-364432C
sc-364432D
5 mg
50 mg
100 mg
500 mg
1 g
$147.00
$1029.00
$1632.00
$3264.00
$4296.00
1
(1)

O BI 2536 é um inibidor da PLK1. Embora iniba a PLK1, pode influenciar indiretamente a interação da proteína Kizuna Centrosomal com a PLK1.

BI 2536

755038-02-9sc-364431
sc-364431A
5 mg
50 mg
$148.00
$515.00
8
(1)

O Volasertib é outro inibidor da PLK1, que afecta potencialmente os processos em que a proteína centrossomal Kizuna e a PLK1 interagem.

GSK461364

929095-18-1sc-364504
sc-364504A
10 mg
50 mg
$500.00
$1540.00
(0)

O GSK461364 é um inibidor seletivo da PLK1, podendo influenciar indiretamente a função da proteína centrossomal Kizuna através da modulação da PLK1.

NVP-BHG712

940310-85-0sc-364554
sc-364554A
5 mg
50 mg
$232.00
$1764.00
(0)

O GW843682X é um inibidor da PLK1, que pode modular indiretamente a função da proteína centrossomal Kizuna ao influenciar a PLK1.

RO-3306

872573-93-8sc-358700
sc-358700A
sc-358700B
1 mg
5 mg
25 mg
$65.00
$160.00
$320.00
37
(1)

O RO3280 é um inibidor da PLK1, que poderá ter um impacto indireto na proteína centrossomal Kizuna através da modulação da via da PLK1.

LFM-A13

62004-35-7sc-203623
sc-203623A
10 mg
50 mg
$119.00
$670.00
(1)

O LFM-A13 é um inibidor da quinase do tipo Polo, que pode influenciar indiretamente a proteína centrossomal Kizuna através da sua ação sobre a PLK1.

Purvalanol B

212844-54-7sc-361300
sc-361300A
10 mg
50 mg
$199.00
$846.00
(1)

O purvalanol A, um inibidor da quinase dependente da ciclina, pode afetar indiretamente a proteína centrossomal Kizuna através das vias de regulação do ciclo celular.