DSN1 Ativadores
DSN1," or "Dosage Suppression of NNF1," is a gene that encodes a protein component of the kinetochore complex. The kinetochore is a vital structure composed of proteins assembled on the centromere, which is the part of a chromosome that links sister chromatids. During cell division, specifically mitosis and meiosis, kinetochores are responsible for the attachment of chromosomes to the spindle microtubules, enabling their accurate segregation into daughter cells.The DSN1 protein is a part of the MIS12 complex within the kinetochore, which is essential for the proper assembly and function of the kinetochore. It serves as a crucial connection point between the inner kinetochore proteins, which bind directly to the centromeric DNA, and the outer kinetochore proteins, which interact with the spindle microtubules.
DSN1's role is not merely structural; it is also implicated in the signaling pathways that ensure the correct attachment of the kinetochore to the spindle fibers. This includes the spindle assembly checkpoint, a critical surveillance mechanism that prevents the onset of anaphase until all chromosomes are properly attached to the spindle, thus ensuring accurate chromosome segregation and genomic stability.Mutations or dysregulation of the DSN1 gene or protein can lead to chromosomal missegregation, aneuploidy, and contribute to the development of various cancers.
VEJA TAMBÉM
| Nome do Produto | CAS # | Numero de Catalogo | Quantidade | Preco | Uso e aplicacao | NOTAS |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
O paclitaxel estabiliza os microtúbulos e pode afetar indiretamente o DSN1, alterando as interações cinetocoro-microtúbulo durante a divisão celular. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Um agente despolimerizador de microtúbulos, o Nocodazole, pode influenciar a montagem do fuso e influenciar indiretamente a função do DSN1 no cinetocoro. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Um inibidor da cinesina Eg5, o Monastrol interrompe a formação do fuso, afectando potencialmente o papel do DSN1 no cinetocoro. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
A colchicina liga-se à tubulina e inibe a polimerização dos microtúbulos, afectando indiretamente a função do DSN1 na segregação dos cromossomas. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
A vinblastina, um agente desestabilizador dos microtúbulos, pode influenciar a função dos cinetocoros e afetar indiretamente o DSN1. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
Um inibidor específico do Eg5, este composto perturba a dinâmica do fuso mitótico, afectando potencialmente a função do DSN1. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Um inibidor da quinase Aurora, ZM447439, pode alterar a função do cinetocoro, afectando indiretamente o DSN1. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
Um inibidor de PLK1, o BI 2536, pode perturbar a montagem do fuso e influenciar indiretamente o DSN1 no cinetocoro. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
O Alisertib, um inibidor da quinase Aurora A, pode afetar a montagem do fuso e a função do cinetocoro, afectando indiretamente o DSN1. | ||||||