ZYG11BL Antibody (D-4): sc-515652

ZYG11BL Antibody (D-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZYG11BL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ZYG11BL antibody (D-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZYG11BL, also known as zyg-11 homolog B-like protein, ZER1, Hzyg, or ZYG, is a 766 amino acid protein characterized by the presence of five ARM repeats and three leucine-rich repeats, which are crucial for protein-protein interactions and stability. ZYG11BL plays a significant role as a component of the E3 ubiquitin ligase complex, working alongside CUL-2 and Elongin BC to facilitate the ubiquitination process, which is essential for regulating protein degradation and maintaining cellular homeostasis. The gene encoding ZYG11BL is located on human chromosome 9, a region associated with various genetic disorders, including hereditary hemorrhagic telangiectasia and familial dysautonomia, highlighting ZYG11BL′s importance in both normal physiology and disease states. ZYG11BL expression in diverse tissues such as testis, prostate, skeletal muscle, ovary, small intestine, heart, brain, and pancreas underscores ZYG11BL′s potential involvement in multiple biological processes, making ZYG11BL (D-4) antibody a valuable tool for researchers studying ubiquitin-mediated signaling pathways and their implications in health and disease.

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ZYG11BL Antibody (D-4) References:

1. Meiotic human sperm cells express a leucine-rich homologue of Caenorhabditis elegans early embryogenesis gene, Zyg-11.  |  Féral, C., et al. 2001. Mol Hum Reprod. 7: 1115-22. PMID: 11719588
2. Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p.  |  Zhuang, H., et al. 2006. Arthritis Rheum. 54: 1573-9. PMID: 16645992
3. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components.  |  Vasudevan, S., et al. 2007. EMBO Rep. 8: 279-86. PMID: 17304241
4. Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease).  |  Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
5. Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia.  |  Burmeister, T., et al. 2007. Haematologica. 92: 1699-702. PMID: 18055996
6. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing.  |  Gold-von Simson, G., et al. 2009. Pediatr Res. 65: 341-6. PMID: 19033881
7. Organization of the amplified type I interferon gene cluster and associated chromosome regions in the interphase nucleus of human osteosarcoma cells.  |  Zeitz, MJ., et al. 2009. Chromosome Res. 17: 305-19. PMID: 19283497
8. Neuroimaging supports central pathology in familial dysautonomia.  |  Axelrod, FB., et al. 2010. J Neurol. 257: 198-206. PMID: 19705052
9. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.  |  Timms, RT., et al. 2019. Science. 365: PMID: 31273098
10. Molecular basis for recognition of Gly/N-degrons by CRL2ZYG11B and CRL2ZER1.  |  Yan, X., et al. 2021. Mol Cell. 81: 3262-3274.e3. PMID: 34214466
11. ZER1 Contributes to the Carcinogenic Activity of High-Risk HPV E7 Proteins.  |  Nouel, J. and White, EA. 2022. mBio. 13: e0203322. PMID: 36346242
12. CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation.  |  Li, Y., et al. 2022. Nat Commun. 13: 7636. PMID: 36496439

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZYG11BL Antibody (D-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZYG11BL Antibody (D-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZYG11BL Antibody (D-4) Specifications

Alternate Product Name: ZYG11BL

Product Clone Name: D-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 488-766

Epitope Target: ZYG11BL

Epitope Species: human

Product Reactivity/Detection: ZYG11BL

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZYG11BL Antibody (D-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin