ZPI Antibody (F-12): sc-393486

ZPI Antibody (F-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZPI protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZPI (F-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZPI, also known as SERPINA10, is a 444 amino acid secreted protein primarily produced in the liver and plays a crucial role as a Protein Z-dependent protease inhibitor. ZPI is essential for regulating blood coagulation, as ZPI inhibits activated pro-coagulation factors X and XI in the presence of calcium and phospholipids, thereby preventing excessive clot formation and maintaining hemostatic balance. ZPI is a member of the serpin protein family and features five potential N-linked glycosylation sites, with a critical tyrosine residue at position 387; disruption of this residue can lead to loss of function. Deficiencies or mutations in ZPI can increase the risk of venous thrombosis, highlighting ZPI′s importance in vascular health.

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ZPI Antibody (F-12) References:

1. Characterization of the protein Z-dependent protease inhibitor.  |  Han, X., et al. 2000. Blood. 96: 3049-55. PMID: 11049983
2. Protein Z-dependent regulation of coagulation.  |  Broze, GJ. 2001. Thromb Haemost. 86: 8-13. PMID: 11487045
3. Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis.  |  Al-Shanqeeti, A., et al. 2005. Thromb Haemost. 93: 411-3. PMID: 15735788
4. Down-regulation of factor IXa in the factor Xase complex by protein Z-dependent protease inhibitor.  |  Heeb, MJ., et al. 2005. J Biol Chem. 280: 33819-25. PMID: 16093243
5. Human endothelial cells synthesize protein Z, but not the protein Z dependent inhibitor.  |  Vasse, M., et al. 2006. Thromb Haemost. 95: 519-23. PMID: 16525581
6. A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis.  |  Corral, J., et al. 2006. Blood. 108: 177-83. PMID: 16527896
7. Polymorphisms of the protein Z-dependent protease inhibitor (ZPI) gene and the risk of venous thromboembolism.  |  Razzari, C., et al. 2006. Thromb Haemost. 95: 909-10. PMID: 16676092
8. [Bronchial perforation in tuberculosis of the lymph nodes].  |  Marin, S. 1967. Med Glas. 21: 62-6. PMID: 6079143

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZPI Antibody (F-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZPI Antibody (F-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZPI Antibody (F-12) Specifications

Alternate Product Name: ZPI

Product Clone Name: F-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 101-237

Epitope Target: ZPI

Epitope Species: human

Product Reactivity/Detection: ZPI

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZPI Antibody (F-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin