ZnT-5 Antibody (2F10-2B8): sc-517038
- ZnT-5 Antibody (2F10-2B8) is a mouse monoclonal IgG2b κ ZnT-5 antibody provided at 100 µg/ml
- raised against amino acids 1-118 representing full length ZnT-5 of human origin
- recommended for detection of ZnT-5 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ZnT-5 Antibody (2F10-2B8). This work is in progress.
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ZnT-5 Antibody (2F10-2B8) is a mouse monoclonal IgG2b kappa light chain antibody that detects ZnT-5 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ZnT-5 antibody (2F10-2B8) is available as a non-conjugated format. ZnT-5, also known as SLC30A5, ZNTL1, or ZTL1, is a crucial zinc transporter consisting of 765 amino acids that plays a vital role in maintaining zinc homeostasis within cellular compartments, particularly in the trans-Golgi network. ZnT-5 is essential for regulating intracellular supply of zinc, which is necessary for various cellular functions, including enzyme activity and transcription factor regulation. ZnT-5 is predominantly expressed in the liver, pancreas, and kidney, where ZnT-5 facilitates zinc transport into vesicles and the Golgi apparatus, thereby contributing to processes such as insulin crystallization in pancreatic beta cells. ZnT-5 is expressed in two isoforms due to alternative splicing, and ZnT-5 expression is significantly upregulated in response to zinc depletion, highlighting an adaptive role in cellular zinc management.
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ZnT-5 Antibody (2F10-2B8) References:
- Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. | Kambe, T., et al. 2002. J Biol Chem. 277: 19049-55. PMID: 11904301
- A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. | Cragg, RA., et al. 2002. J Biol Chem. 277: 22789-97. PMID: 11937503
- Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. | Devergnas, S., et al. 2004. Biochem Pharmacol. 68: 699-709. PMID: 15276077
- Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane. | Suzuki, T., et al. 2005. J Biol Chem. 280: 637-43. PMID: 15525635
- Homeostatic regulation of zinc transporters in the human small intestine by dietary zinc supplementation. | Cragg, RA., et al. 2005. Gut. 54: 469-78. PMID: 15753530
- Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells. | Ishihara, K., et al. 2006. J Biol Chem. 281: 17743-50. PMID: 16636052
- Splice variants of the human zinc transporter ZnT5 (SLC30A5) are differentially localized and regulated by zinc through transcription and mRNA stability. | Jackson, KA., et al. 2007. J Biol Chem. 282: 10423-31. PMID: 17234632
- ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells. | Valentine, RA., et al. 2007. J Biol Chem. 282: 14389-93. PMID: 17355957
- Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. | Overbeck, S., et al. 2008. J Leukoc Biol. 83: 368-80. PMID: 17971500
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZnT-5 Antibody (2F10-2B8) | sc-517038 | 100 µg/ml | $322.00 |