ZnT-5 Activators
ZnT-5 activators are comprised of chemical compounds that exert their influence by modulating the homeostasis and bioavailability of zinc within cellular compartments, which is crucial for the proper function of ZnT-5, the protein encoded by the SLC30A5 gene responsible for zinc translocation. For instance, zinc pyrithione, by supplying zinc ions, directly correlates with the functional requirement of ZnT-5, facilitating its role in transporting zinc into vesicles. Similarly, histidine enhances the bioavailability of zinc, which ZnT-5 actively transports, thus amplifying its functional activity. Compounds like nicotinamide and prostaglandin E2 may not directly bind to ZnT-5, but their role in upregulating cellular processes that require zinc indicates a potential for increased ZnT-5-mediated zinc transport. Additionally, molecules such as quercetin and epigallocatechin gallate, known for their metal ion chelation capacity, may necessitate a compensatory upregulation of ZnT-5 activity to maintain zinc equilibrium within cells.
Further enhancement of ZnT-5 activity can be inferred from the actions of compounds such as D-Penicillamine and clioquinol; these act as chelators or ionophores for zinc, thereby possibly creating a cellular state that demands greater ZnT-5 activity for zinc compartmentalization. The interplay of resveratrol and sulfasalazine with metal ion transport processes also suggests their indirect role in potentiating ZnT-5's function by altering the intracellular zinc landscape, demanding efficient transport to specific organelles. Additionally, tamoxifen and tetrathiomolybdate, through their interactions with metal ions, can influence the function of ZnT-5 by modifying intracellular zinc distribution, thereby indirectly necessitating an increase in ZnT-5 transporter activity to restore zinc equilibrium. Collectively, these compounds, by influencing the cellular zinc milieu, necessitate the enhanced activity of ZnT-5 to fulfill the cell's requirements for zinc distribution and storage, ensuring the metal's availability for numerous physiological processes.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
As a source of zinc ions, zinc pyrithione can increase the intracellular concentration of zinc, which is necessary for the functional activity of ZnT-5, as ZnT-5 is responsible for zinc transport into vesicles. | ||||||
L-Histidine | 71-00-1 | sc-394101 sc-394101A sc-394101B sc-394101C sc-394101D | 25 g 100 g 250 g 500 g 1 kg | $54.00 $84.00 $189.00 $204.00 $339.00 | 1 | |
Histidine forms complexes with zinc ions, potentially increasing the bioavailability of zinc, which can be transported by ZnT-5 into the Golgi apparatus, thus enhancing its zinc transport activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide can increase intracellular NAD+ levels, which has been linked to the regulation of metal ion homeostasis, potentially increasing the demand for ZnT-5 activity in zinc metabolism. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can chelate metal ions and may alter zinc homeostasis, thereby indirectly necessitating increased ZnT-5 activity to maintain zinc equilibrium within cells. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 has been shown to influence zinc signaling. Its presence could enhance the activity of ZnT-5 by increasing the cellular requirement for zinc transportation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This catechin has been shown to interact with metal ions and may modulate zinc transporter activities indirectly, including ZnT-5, by altering the intracellular zinc buffering capacity. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
Penicillamine chelates zinc ions, potentially increasing the intracellular demand for zinc and thereby enhancing the transport activity of ZnT-5. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $45.00 $115.00 | 2 | |
Clioquinol is a zinc ionophore which can increase cellular zinc uptake; this may subsequently enhance the activity of ZnT-5 as it works to sequester zinc into organelles. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can modulate various metal ion transporters and may indirectly enhance ZnT-5 activity by influencing zinc homeostasis within cells. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine can affect metal ion homeostasis and could indirectly enhance ZnT-5 function by increasing the cellular requirement for zinc compartmentalization. | ||||||