ZNF541 Antibody (E-8): sc-515333
- ZNF541 Antibody (E-8) is a mouse monoclonal IgG1 κ ZNF541 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-24 at the N-terminus of ZNF541 of human origin
- ZNF541 Antibody (E-8) is recommended for detection of ZNF541 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ZNF541 Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ZNF541 Antibody (E-8) for WB applications. These reagents are now offered in bundles with ZNF541 Antibody (E-8) (see ordering information below).
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ZNF541 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZNF541 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZNF541 (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZNF541, also known as zinc finger protein 541, is a crucial nuclear protein composed of 1,365 amino acids that plays a significant role in chromatin remodeling, particularly during spermatogenesis. ZNF541 exists in three alternatively spliced isoforms and features a SANT domain, an ELM2 domain, and five C2H2-type zinc fingers, which are essential for DNA binding and transcriptional regulation. ZNF541 interacts with heat shock protein A2 (HSPA2) and histone deacetylase 1 (HDAC1), highlighting involvement in gene expression regulation through chromatin modification. The gene encoding ZNF541 is located on human chromosome 19q13.33, a region that encompasses over 63 million bases and approximately 1,400 genes, including several members of the immunoglobulin superfamily and various cell adhesion molecules. ZNF541′s ability to modulate chromatin structure and gene expression underscores importance in cellular processes and potential implications in reproductive biology and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ZNF541 Antibody (E-8) References:
- C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers. | Wang, L., et al. 2000. Clin Cancer Res. 6: 2988-93. PMID: 10955775
- KRAB-containing zinc-finger repressor proteins. | Urrutia, R. 2003. Genome Biol. 4: 231. PMID: 14519192
- Comparative human-mouse-rat sequence analysis of the ICAM gene cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q. | Leeb, T. and Müller, M. 2004. Gene. 343: 239-44. PMID: 15588578
- A family of human zinc finger proteins that bind methylated DNA and repress transcription. | Filion, GJ., et al. 2006. Mol Cell Biol. 26: 169-81. PMID: 16354688
- A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors. | Huntley, S., et al. 2006. Genome Res. 16: 669-77. PMID: 16606702
- [Progress in the study of KRAB zinc finger protein]. | Tian, CY., et al. 2006. Yi Chuan. 28: 1451-6. PMID: 17098717
- The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family. | Teglund, S., et al. 1994. Genomics. 23: 669-84. PMID: 7851896
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZNF541 Antibody (E-8) | sc-515333 | 200 µg/ml | $322.00 | |||
ZNF541 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-528022 | 200 µg Ab; 10 µg BP | $361.00 | |||
ZNF541 Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-533395 | 200 µg Ab; 20 µg BP | $361.00 | |||
ZNF541 Antibody (E-8) AC | sc-515333 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ZNF541 Antibody (E-8) HRP | sc-515333 HRP | 200 µg/ml | $322.00 | |||
ZNF541 Antibody (E-8) FITC | sc-515333 FITC | 200 µg/ml | $336.00 | |||
ZNF541 Antibody (E-8) PE | sc-515333 PE | 200 µg/ml | $349.00 | |||
ZNF541 Antibody (E-8) Alexa Fluor® 488 | sc-515333 AF488 | 200 µg/ml | $364.00 | |||
ZNF541 Antibody (E-8) Alexa Fluor® 546 | sc-515333 AF546 | 200 µg/ml | $364.00 | |||
ZNF541 Antibody (E-8) Alexa Fluor® 594 | sc-515333 AF594 | 200 µg/ml | $364.00 | |||
ZNF541 Antibody (E-8) Alexa Fluor® 647 | sc-515333 AF647 | 200 µg/ml | $364.00 | |||
ZNF541 Antibody (E-8) Alexa Fluor® 680 | sc-515333 AF680 | 200 µg/ml | $364.00 | |||
ZNF541 Antibody (E-8) Alexa Fluor® 790 | sc-515333 AF790 | 200 µg/ml | $364.00 | |||
ZNF541 (E-8) Neutralizing Peptide | sc-515333 P | 100 µg/0.5 ml | $69.00 |