ZNF509 Antibody (3502C2a): sc-81144

ZNF509 Antibody (3502C2a) is a mouse monoclonal IgG1 antibody that detects the ZNF509 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-ZNF509 antibody (3502C2a) is available as a non-conjugated format. ZNF509 protein is a member of the Krüppel C2H2-type zinc-finger protein family, characterized by multiple zinc-finger motifs, which are essential for DNA-binding capabilities. This structural feature allows ZNF509 to interact with specific DNA sequences, thereby playing a crucial role in gene expression regulation. ZNF509 is predominantly localized in the nucleus, where ZNF509 is involved in transcriptional regulation, potentially influencing cellular processes such as proliferation and differentiation. ZNF509 has been implicated in tumor suppression, showing high expression in normal epithelial cells but significant repression in various tumor tissues, including colon, lung, and skin. This suggests ZNF509 may function as a critical regulator in maintaining normal cellular functions and preventing oncogenic transformations.

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ZNF509 Antibody (3502C2a) References:

1. The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor.  |  Sun, Y., et al. 2003. IUBMB Life. 55: 127-31. PMID: 12822888
2. Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome.  |  Englbrecht, CC., et al. 2004. BMC Genomics. 5: 39. PMID: 15236668
3. A novel subfamily of zinc finger genes involved in embryonic development.  |  Nakamura, M., et al. 2004. J Cell Biochem. 93: 887-95. PMID: 15449319
4. A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE.  |  Li, Y., et al. 2006. Mol Biol Rep. 33: 287-94. PMID: 17089209
5. Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs.  |  O'Geen, H., et al. 2007. PLoS Genet. 3: e89. PMID: 17542650
6. Identification of a novel human zinc finger gene, ZNF438, with transcription inhibition activity.  |  Zhong, Z., et al. 2007. J Biochem Mol Biol. 40: 517-24. PMID: 17669267
7. Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress.  |  Jeon, BN., et al. 2014. Nucleic Acids Res. 42: 11447-61. PMID: 25245946

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF509 Antibody (3502C2a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF509 Antibody (3502C2a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF509 Antibody (3502C2a) Specifications

Alternate Product Name: ZNF509

Product Clone Name: 3502C2a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: ZNF509

Epitope Species: human

Product Reactivity/Detection: ZNF509

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZNF509 Antibody (3502C2a): N/A