ZNF452 Antibody (G-11): sc-514003

ZNF452 Antibody (G-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects ZNF452 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZNF452 Antibody (G-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZNF452, also known as SCAN domain-containing protein 3, plays a crucial role in gene regulation due to its structure, which includes one integrase catalytic domain and one SCAN box domain. These domains are essential for ZNF452′s function in transcriptional regulation, as they facilitate interactions with DNA and other regulatory proteins. The presence of the SCAN box domain is particularly significant, as this domain is involved in protein-protein interactions that can modulate the activity of transcription factors, thereby influencing various cellular processes. ZNF452 is encoded by a gene located on chromosome 6, a region associated with several diseases, including early onset intestinal cancer and various neuropsychiatric disorders. ZNF452′s ability to interact with other proteins and involvement in chromatin remodeling highlight ZNF452′s importance in maintaining cellular homeostasis and potential role in cancer susceptibility.

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ZNF452 Antibody (G-11) References:

1. Zinc finger proteins: new insights into structural and functional diversity.  |  Laity, JH., et al. 2001. Curr Opin Struct Biol. 11: 39-46. PMID: 11179890
2. Multiple modes of RNA recognition by zinc finger proteins.  |  Hall, TM. 2005. Curr Opin Struct Biol. 15: 367-73. PMID: 15963892
3. The SCAN domain family of zinc finger transcription factors.  |  Edelstein, LC. and Collins, T. 2005. Gene. 359: 1-17. PMID: 16139965
4. The contribution of transposable elements to Bos taurus gene structure.  |  Almeida, LM., et al. 2007. Gene. 390: 180-9. PMID: 17157447
5. Context-dependent DNA recognition code for C2H2 zinc-finger transcription factors.  |  Liu, J. and Stormo, GD. 2008. Bioinformatics. 24: 1850-7. PMID: 18586699
6. The arrestin domain-containing 3 protein regulates body mass and energy expenditure.  |  Patwari, P., et al. 2011. Cell Metab. 14: 671-83. PMID: 21982743
7. Multiple genes encoding zinc finger domains are expressed in human T cells.  |  Thiesen, HJ. 1990. New Biol. 2: 363-74. PMID: 2288909
8. ZNF452 facilitates tumor proliferation and invasion via activating AKT-GSK3β signaling pathway and predicts poor prognosis of non-small cell lung cancer patients.  |  Zhang, X., et al. 2017. Oncotarget. 8: 38863-38875. PMID: 28418919
9. Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer.  |  Moroz, A., et al. 2020. Clin Cancer Res. 26: 3608-3615. PMID: 32341034
10. Finger proteins and DNA-specific recognition: distinct patterns of conserved amino acids suggest different evolutionary modes.  |  Payre, F. and Vincent, A. 1988. FEBS Lett. 234: 245-50. PMID: 3292287
11. Preclinical Development in Radiopharmaceutical Therapy for Prostate Cancer.  |  Alati, S., et al. 2023. Semin Nucl Med. 53: 663-686. PMID: 37468417
12. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs.  |  Rosenfeld, R. and Margalit, H. 1993. J Biomol Struct Dyn. 11: 557-70. PMID: 8129873

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF452 Antibody (G-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF452 Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF452 Antibody (G-11) Specifications

Alternate Product Name: ZNF452

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1237-1261

Epitope Target: ZNF452

Epitope Species: human

Product Reactivity/Detection: ZNF452

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ZNF452 Antibody (G-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin