ZNF279 Antibody (F-4): sc-515438

ZNF279 Antibody (F-4) is a mouse monoclonal IgA kappa light chain antibody that detects ZNF279 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZNF279 antibody (F-4) is available as the non-conjugated form. ZNF279, also known as zinc finger protein 279, ZNF280B, SUHW2, and ZNF632, is a crucial nuclear protein composed of 543 amino acids and features four C2H2-type zinc fingers, which are essential for its role as a transcription factor. Located on human chromosome 22, ZNF279 plays a significant role in gene regulation, and proper function is vital for maintaining cellular homeostasis and influencing developmental processes. ZNF279′s ability to bind DNA through zinc-finger motifs allows modulation of target gene expression, which is particularly important in various diseases, including neurodevelopmental disorders. Mutations in genes on chromosome 22, where ZNF279 is encoded, have been linked to conditions such as Phelan-McDermid syndrome, Neurofibromatosis type 2, autism, and schizophrenia, highlighting the importance of studying ZNF279 for understanding implications in health and disease.

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ZNF279 Antibody (F-4) References:

1. Chromosome 22 workshop report.  |  Schwab, SG. and Wildenauer, DB. 1999. Am J Med Genet. 88: 276-8. PMID: 10374745
2. Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line.  |  Nishioka, M., et al. 2000. Oncogene. 19: 6251-60. PMID: 11175339
3. The SCAN domain family of zinc finger transcription factors.  |  Edelstein, LC. and Collins, T. 2005. Gene. 359: 1-17. PMID: 16139965
4. Deletion 22q11: spectrum of associated disorders.  |  Hay, BN. 2007. Semin Pediatr Neurol. 14: 136-9. PMID: 17980310
5. Context-dependent DNA recognition code for C2H2 zinc-finger transcription factors.  |  Liu, J. and Stormo, GD. 2008. Bioinformatics. 24: 1850-7. PMID: 18586699
6. Multiple genes encoding zinc finger domains are expressed in human T cells.  |  Thiesen, HJ. 1990. New Biol. 2: 363-74. PMID: 2288909
7. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs.  |  Rosenfeld, R. and Margalit, H. 1993. J Biomol Struct Dyn. 11: 557-70. PMID: 8129873

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF279 Antibody (F-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF279 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF279 Antibody (F-4) Specifications

Alternate Product Name: ZNF279

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 521-535

Epitope Target: ZNF279

Epitope Species: human

Product Reactivity/Detection: ZNF279

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZNF279 Antibody (F-4): P: Blocking Peptide