ZNF133 Antibody (9V2): sc-130414

ZNF133 Antibody (9V2) is a mouse monoclonal IgG2a kappa light chain antibody that detects ZNF133 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-ZNF133 antibody (9V2) is available as a non-conjugated format. ZNF133 protein, also known as Zinc finger protein 133 or ZNF150, is a crucial transcriptional regulator composed of 654 amino acids and is expressed in various human tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. ZNF133 includes a Krüppel-type DNA-binding domain and a KRAB domain. The KRAB domain interacts with KAP1, facilitating recruitment of histone-modifying proteins that play a vital role in chromatin remodeling and gene expression regulation. This interaction underscores ZNF133′s importance in transcriptional repression, as the KRAB domain functions as a potent transcriptional repression domain, with activity potentially enhanced by Protein Inhibitor of Activated STAT Protein 1 (PIAS1). ZNF133′s ability to modulate gene expression through these mechanisms highlights relevance in various biological processes and potential implications in disease states where transcriptional regulation is disrupted.

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ZNF133 Antibody (9V2) References:

1. Detection of gene amplification by genomic hybridization to cDNA microarrays.  |  Heiskanen, MA., et al. 2000. Cancer Res. 60: 799-802. PMID: 10706083
2. Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice.  |  Ehringer, MA., et al. 2002. Alcohol Clin Exp Res. 26: 1603-8. PMID: 12436047
3. Interferon-gamma suppresses S100A4 transcription independently of apoptosis or cell cycle arrest.  |  Andersen, K., et al. 2003. Br J Cancer. 88: 1995-2001. PMID: 12799648
4. Human alcoholism studies of genes identified through mouse quantitative trait locus analysis.  |  Ehringer, MA., et al. 2002. Addict Biol. 7: 365-71. PMID: 14578011
5. PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity.  |  Lee, SJ., et al. 2007. Exp Mol Med. 39: 450-7. PMID: 17934332
6. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.  |  Tommerup, N. and Vissing, H. 1995. Genomics. 27: 259-64. PMID: 7557990
7. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins.  |  Vissing, H., et al. 1995. FEBS Lett. 369: 153-7. PMID: 7649249

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF133 Antibody (9V2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF133 Antibody (9V2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF133 Antibody (9V2) Specifications

Alternate Product Name: ZNF133

Product Clone Name: 9V2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 121-231

Epitope Target: ZNF133

Epitope Species: human

Product Reactivity/Detection: ZNF133

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZNF133 Antibody (9V2): N/A