ZFYVE1 Antibody (A-9): sc-515049
- ZFYVE1 Antibody (A-9) is a mouse monoclonal IgG1 κ ZFYVE1 antibody provided at 200 µg/ml
- raised against amino acids 402-479 mapping within an internal region of ZFYVE1 of human origin
- ZFYVE1 Antibody (A-9) is recommended for detection of ZFYVE1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ZFYVE1 Antibody (A-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ZFYVE1 Antibody (A-9) for WB applications. These reagents are now offered in bundles with ZFYVE1 Antibody (A-9) (see ordering information below).
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ZFYVE1 Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZFYVE1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZFYVE1 Antibody (A-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZFYVE1, also known as zinc finger FYVE domain-containing protein 1, is a 777 amino acid protein primarily localized to the cisternal stacks of the Golgi apparatus, which plays a crucial role in intracellular trafficking and membrane dynamics. The presence of two FYVE-type zinc fingers in ZFYVE1′s structure allows binding to phosphatidylinositol 3-phosphate, a lipid essential for endosomal and Golgi membrane interactions, facilitating transport of proteins and lipids within cells. This function maintains cellular homeostasis and ensures proper signaling pathways, as disruptions in ZFYVE1 activity can lead to various cellular dysfunctions. The gene encoding ZFYVE1 is located on human chromosome 14, harboring over 700 genes, including those associated with critical conditions such as Alzheimer′s disease and α1-antitrypsin deficiency.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ZFYVE1 Antibody (A-9) References:
- Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library. | Derubeis, AR., et al. 2000. Gene. 255: 195-203. PMID: 11024279
- Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. | Cheung, PC., et al. 2001. Biochem J. 355: 113-21. PMID: 11256955
- FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. | Ridley, SH., et al. 2001. J Cell Sci. 114: 3991-4000. PMID: 11739631
- Linkage to chromosome 14q in Alzheimer's disease (AD) patients without psychotic symptoms. | Avramopoulos, D., et al. 2005. Am J Med Genet B Neuropsychiatr Genet. 132B: 9-13. PMID: 15389761
- Genotype-phenotype relationships of presenilin-1 mutations in Alzheimer's disease: an update. | Larner, AJ. and Doran, M. 2009. J Alzheimers Dis. 17: 259-65. PMID: 19221408
- Alpha-1-antitrypsin phenotypes in adult liver disease patients. | Topic, A., et al. 2009. Ups J Med Sci. 114: 228-34. PMID: 19961268
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZFYVE1 Antibody (A-9) | sc-515049 | 200 µg/ml | $316.00 | |||
ZFYVE1 Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-531274 | 200 µg Ab; 10 µg BP | $354.00 | |||
ZFYVE1 Antibody (A-9): m-IgGκ BP-HRP Bundle | sc-524916 | 200 µg Ab, 40 µg BP | $354.00 | |||
ZFYVE1 Antibody (A-9): m-IgG1 BP-HRP Bundle | sc-544464 | 200 µg Ab; 20 µg BP | $354.00 | |||
ZFYVE1 Antibody (A-9) AC | sc-515049 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ZFYVE1 Antibody (A-9) HRP | sc-515049 HRP | 200 µg/ml | $316.00 | |||
ZFYVE1 Antibody (A-9) FITC | sc-515049 FITC | 200 µg/ml | $330.00 | |||
ZFYVE1 Antibody (A-9) PE | sc-515049 PE | 200 µg/ml | $343.00 | |||
ZFYVE1 Antibody (A-9) Alexa Fluor® 488 | sc-515049 AF488 | 200 µg/ml | $357.00 | |||
ZFYVE1 Antibody (A-9) Alexa Fluor® 546 | sc-515049 AF546 | 200 µg/ml | $357.00 | |||
ZFYVE1 Antibody (A-9) Alexa Fluor® 594 | sc-515049 AF594 | 200 µg/ml | $357.00 | |||
ZFYVE1 Antibody (A-9) Alexa Fluor® 647 | sc-515049 AF647 | 200 µg/ml | $357.00 | |||
ZFYVE1 Antibody (A-9) Alexa Fluor® 680 | sc-515049 AF680 | 200 µg/ml | $357.00 | |||
ZFYVE1 Antibody (A-9) Alexa Fluor® 790 | sc-515049 AF790 | 200 µg/ml | $357.00 |