ZFP2 Antibody (E-9): sc-514011

ZFP2 Antibody (E-9) is a mouse monoclonal IgG3 antibody that detects ZFP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZFP2 antibody (E-9) is available as the non-conjugated form. ZFP2, also known as zinc finger protein 2 homolog, is a crucial transcription factor composed of 461 amino acids and characterized by thirteen C2H2-type zinc fingers, which facilitate DNA binding. ZFP2 primarily localizes to the nucleus, where ZFP2 plays a significant role in regulating gene expression, thereby influencing various cellular processes such as differentiation, development, and response to environmental stimuli. The presence of zinc finger motifs is essential for function, as these allow ZFP2 to interact with specific DNA sequences, modulating target gene transcription. ZFP2 is encoded by a gene located on human chromosome 5, a region associated with several genetic disorders, including Cockayne syndrome and familial adenomatous polyposis. ZFP2′s ability to recruit histone-modifying proteins through KAP1 interaction further underscores importance in chromatin remodeling and gene regulation. This makes ZFP2 a valuable target for research in developmental biology and cancer studies, as understanding function and regulation could provide insights into therapeutic strategies for diseases linked to aberrant gene expression.

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ZFP2 Antibody (E-9) References:

1. Familial adenomatous polyposis and mental retardation caused by a de novo chromosomal deletion at 5q15-q22: report of a case.  |  Finch, R., et al. 2005. Dis Colon Rectum. 48: 2148-52. PMID: 16228830
2. Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.  |  Anindya, R., et al. 2007. Mol Cell. 28: 386-97. PMID: 17996703
3. Haematological & molecular profile of acute myelogenous leukaemia in India.  |  Sazawal, S., et al. 2009. Indian J Med Res. 129: 256-61. PMID: 19491417
4. Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities.  |  Ravandi, F., et al. 2009. Cancer. 115: 5746-51. PMID: 19795507
5. Characterization of a de novo complex chromosomal rearrangement in a patient with cri-du-chat and trisomy 5p syndromes.  |  Vera-Carbonell, A., et al. 2009. Am J Med Genet A. 149A: 2513-21. PMID: 19842199
6. Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19.  |  Rousseau-Merck, MF., et al. 1993. Hum Genet. 92: 583-7. PMID: 8262519
7. The mutational spectrum in Treacher Collins syndrome reveals a predominance of mutations that create a premature-termination codon.  |  Edwards, SJ., et al. 1997. Am J Hum Genet. 60: 515-24. PMID: 9042910
8. Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome.  |  Crawford, MJ., et al. 1997. Mamm Genome. 8: 841-5. PMID: 9337397
9. Confirmation of homozygosity for a single nucleotide substitution mutation in a Cockayne syndrome patient using monoallelic mutation analysis in somatic cell hybrids.  |  McDaniel, LD., et al. 1997. Hum Mutat. 10: 317-21. PMID: 9338586

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZFP2 Antibody (E-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZFP2 Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZFP2 Antibody (E-9) Specifications

Alternate Product Name: ZFP2

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ lambda light chain

Amino Acids: 2-19

Epitope Target: ZFP2

Epitope Species: human

Product Reactivity/Detection: ZFP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZFP2 Antibody (E-9): P: Blocking Peptide