ZBTB4 Antibody (A-7): sc-514883

ZBTB4 Antibody (A-7) is a mouse monoclonal IgM antibody that detects ZBTB4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZBTB4 antibody (A-7) is available as the non-conjugated form. ZBTB4, also known as KAISO-L1, plays a crucial role in transcriptional regulation, influencing gene expression in various biological processes. ZBTB4 functions as a nuclear protein composed of 1,013 amino acids, featuring one BTB (POZ) domain and six C2H2-type zinc fingers, which are essential for DNA-binding capabilities. These zinc fingers allow ZBTB4 to interact with specific DNA sequences, thereby modulating target gene transcription. ZBTB4 undergoes phosphorylation and downregulation by HIPK2, a process that can impact regulatory functions. ZBTB4 is encoded on human chromosome 17, a region encompassing over 2.5% of the human genome and containing more than 1,200 genes, highlighting ZBTB4′s importance in genomic regulation and cellular function.

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ZBTB4 Antibody (A-7) References:

1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.  |  Nagase, T., et al. 2000. DNA Res. 7: 143-50. PMID: 10819331
2. A family of human zinc finger proteins that bind methylated DNA and repress transcription.  |  Filion, GJ., et al. 2006. Mol Cell Biol. 26: 169-81. PMID: 16354688
3. Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation.  |  Weber, A., et al. 2008. EMBO J. 27: 1563-74. PMID: 18451802
4. The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4.  |  Yamada, D., et al. 2009. Oncogene. 28: 2535-44. PMID: 19448668
5. Zinc fingers: gilt by association.  |  Evans, RM. and Hollenberg, SM. 1988. Cell. 52: 1-3. PMID: 3125980
6. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs.  |  Rosenfeld, R. and Margalit, H. 1993. J Biomol Struct Dyn. 11: 557-70. PMID: 8129873

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZBTB4 Antibody (A-7) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-ZBTB4 Antibody (A-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZBTB4 Antibody (A-7) Specifications

Alternate Product Name: ZBTB4

Product Clone Name: A-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 614-633

Epitope Target: ZBTB4

Epitope Species: human

Product Reactivity/Detection: ZBTB4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for ZBTB4 Antibody (A-7): P: Blocking Peptide