ZBTB20 Antibody (E-11): sc-515370

ZBTB20 Antibody (E-11) is a mouse monoclonal IgG1 antibody that detects ZBTB20 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZBTB20 (E-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZBTB20, also known as zinc finger and BTB domain containing 20, is a 741 amino acid transcription factor that plays a crucial role in regulating gene expression, particularly in hematopoiesis and immune responses. ZBTB20 is characterized by nuclear localization and contains one BTB (POZ) domain along with five C2H2-type zinc fingers, which are essential for DNA-binding capabilities. ZBTB20′s ability to exist as either a monomer or a homodimer enhances functional versatility, allowing modulation of transcriptional activity in various biological contexts. Additionally, multiple isoforms resulting from alternative splicing events further underscore the complexity of regulatory functions. Anti-ZBTB20 antibody (E-11) helps researchers gain valuable insights into mechanisms of oncogenesis and immune system regulation, making this tool indispensable for studies in molecular biology and immunology.

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ZBTB20 Antibody (E-11) References:

1. Assignment of the human zinc finger gene, ZNF288, to chromosome 3 band q13.2 by radiation hybrid mapping and fluorescence in situ hybridisation.  |  Harboe, TL., et al. 2000. Cytogenet Cell Genet. 89: 156-7. PMID: 10965110
2. Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6.  |  Zhang, W., et al. 2001. Biochem Biophys Res Commun. 282: 1067-73. PMID: 11352661
3. Characterization of two novel nuclear BTB/POZ domain zinc finger isoforms. Association with differentiation of hippocampal neurons, cerebellar granule cells, and macroglia.  |  Mitchelmore, C., et al. 2002. J Biol Chem. 277: 7598-609. PMID: 11744704
4. Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice.  |  Nielsen, JV., et al. 2007. Development. 134: 1133-40. PMID: 17301088
5. Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver.  |  Xie, Z., et al. 2008. Proc Natl Acad Sci U S A. 105: 10859-64. PMID: 18669658
6. Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis.  |  Sutherland, AP., et al. 2009. Mol Cell Biol. 29: 2804-15. PMID: 19273596
7. Zbtb20 promotes astrocytogenesis during neocortical development.  |  Nagao, M., et al. 2016. Nat Commun. 7: 11102. PMID: 27000654
8. ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration.  |  Zhang, H., et al. 2018. Cell Death Dis. 9: 462. PMID: 29700307
9. Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury.  |  Doeppner, TR., et al. 2019. Mol Neurobiol. 56: 567-582. PMID: 29748916
10. Primrose syndrome: a phenotypic comparison of patients with a ZBTB20 missense variant versus a 3q13.31 microdeletion including ZBTB20.  |  Juven, A., et al. 2020. Eur J Hum Genet. 28: 1044-1055. PMID: 32071410
11. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.  |  Medeiros de Araújo, JA., et al. 2021. Development. 148: PMID: 34351428
12. ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase‑3 pathway.  |  Duan, P., et al. 2024. Oncol Lett. 28: 358. PMID: 38881713

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZBTB20 Antibody (E-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-ZBTB20 Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZBTB20 Antibody (E-11) Specifications

Alternate Product Name: ZBTB20

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 383-605

Epitope Target: ZBTB20

Epitope Species: human

Product Reactivity/Detection: ZBTB20

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for ZBTB20 Antibody (E-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent