Z-DEVD-AFC MF: C36H38F3N5O14
MW: 821.71
A fluorogenic substrate for caspase-3.

Z-DEVD-AFC

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Synonym: Caspase 3 Apopain Substrate; Fluorogenic substrate for Caspase-3; Z-Asp-Glu-Val-Asp-7-Amino-4-trifluoromethylcoumarin
Application: A fluorogenic substrate for caspase-3
Molecular Weight: 821.71
Molecular Formula: C36H38F3N5O14
* Refer to Certificate of Analysis for lot specific data (including water content).

Z-DEVD-AFC is a fluorogenic substrate for caspase-3. It also acts as a substrate for granzyme B-processed ICE-LAP3, caspase-6, caspase-7, caspase-8, and caspase-10. The reaction can be observed by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.


References

1. Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15: 368. PMID: 10845773
2. Thornberry, N.A., and Lazebnik, Y. 1998. Science. 281: 1312-1316.P MID: 9721091
3. Kluck, R.M., et al. 1997. Science. 275: 1132-1136. PMID: 9027315
4. Talanian, R.V., et al. 1997. J. Biol. Chem. 272: 9677-9682. PMID: 9092497
5. Chinnaiyan, A.M., et al. 1996. Curr. Biol. 6: 897-899. PMID: 8805307
6. Nicholson, D.W., et al. 1995. Nature. 376: 37-43. PMID: 7596430

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/mL), and water.
Storage :
Store at -20° C
Fluoresence :
λex ~400 nm, λem ~505 nm; λex 370-390 nm, λem 500-510 nm; λex 380 nm, λem 500 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25108569
SMILES :
CC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)[[email protected]](CCC(=O)O)NC(=O)[[email protected]](CC(=O)O)NC(=O)OCC3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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