WIPI-3 Antibody (B-7): sc-514194

WIPI-3 Antibody (B-7) is a mouse monoclonal IgM antibody that detects WIPI-3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WIPI-3 (B-7) antibody is available as the non-conjugated form. WIPI-3, also known as WD repeat domain phosphoinositide-interacting protein 3, plays a crucial role in autophagy and endosomal trafficking, processes vital for cellular homeostasis and degradation of damaged organelles. This 344 amino acid protein is characterized by two WD domains and seven WD40 repeats, which contribute to phosphoinositide and protein interactions involved in membrane dynamics. WIPI-3 is predominantly expressed in pancreas, heart, and skeletal muscle, with notable upregulation in uterine and ovarian cancers, highlighting potential as a biomarker for tumor progression. The gene encoding WIPI-3 is located on human chromosome 17, a region significant for high gene density and association with critical tumor suppressor genes like p53 and BRCA1, underscoring WIPI-3′s importance in both normal cellular functions and disease states.

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WIPI-3 Antibody (B-7) References:

1. p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis.  |  Soussi, T., et al. 2000. Hum Mutat. 15: 105-13. PMID: 10612830
2. Distinct pattern of p53 phosphorylation in human tumors.  |  Minamoto, T., et al. 2001. Oncogene. 20: 3341-7. PMID: 11423984
3. Three primary malignancies related to BRCA mutation successively occurring in a BRCA1 185delAG mutation carrier.  |  Piura, B., et al. 2001. Eur J Obstet Gynecol Reprod Biol. 97: 241-4. PMID: 11451557
4. PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49.  |  Jeffries, TR., et al. 2004. Mol Biol Cell. 15: 2652-63. PMID: 15020712
5. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.  |  Proikas-Cezanne, T., et al. 2004. Oncogene. 23: 9314-25. PMID: 15602573
6. Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy.  |  Proikas-Cezanne, T., et al. 2007. FEBS Lett. 581: 3396-404. PMID: 17618624
7. Phylogenetic, structural and functional relationships between WD- and Kelch-repeat proteins.  |  Hudson, AM. and Cooley, L. 2008. Subcell Biochem. 48: 6-19. PMID: 18925367

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WIPI-3 Antibody (B-7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-WIPI-3 Antibody (B-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WIPI-3 Antibody (B-7) Specifications

Alternate Product Name: WIPI-3

Product Clone Name: B-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 281-299

Epitope Target: WIPI-3

Epitope Species: human

Product Reactivity/Detection: WIPI-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for WIPI-3 Antibody (B-7): P: Blocking Peptide