WIPI-1 Antibody (38-W): sc-100901
- WIPI-1 Antibody (38-W) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant WIPI-1 of human origin
- recommended for detection of WIPI-1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for WIPI-1 Antibody (38-W). This work is in progress.
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WIPI-1 Antibody (38-W) is a mouse monoclonal IgG2b antibody that detects WIPI-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). WIPI-1, also known as WD repeat domain, phosphoinositide interacting-1, ATG18, or WIPI49, is a 446 amino acid protein that plays a crucial role in autophagy and protein trafficking, particularly in recycling pathways. WIPI-1 localization to cytoplasmic vesicles, endosomes, clathrin-coated vesicles, and the trans-Golgi network is vital for maintaining cellular homeostasis and regulating the degradation of cellular components. WIPI-1 is ubiquitously expressed, with the highest levels found in the heart, testis, placenta, pancreas, and skeletal muscle, indicating importance in various physiological processes. Notably, WIPI-1 interacts with androgen and estrogen receptors, potentially modulating their function and influencing signaling pathways related to growth and differentiation. WIPI-1 features a unique 7-bladed propeller structure formed by three WD repeats, which is essential for interactions with other proteins, thereby facilitating a role in cellular signaling and trafficking. Additionally, WIPI-1 is expressed in two isoforms, alpha and beta, and WIPI-1 upregulation in various tumors suggests significant involvement in carcinogenesis, making WIPI-1 a potential target for therapeutic intervention and cancer research.
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WIPI-1 Antibody (38-W) References:
- RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3. | Welch, K., et al. 1999. Mol Cell Biol. 19: 8400-11. PMID: 10567565
- RanBP3 enhances nuclear export of active (beta)-catenin independently of CRM1. | Hendriksen, J., et al. 2005. J Cell Biol. 171: 785-97. PMID: 16314428
- Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy. | Vergne, I., et al. 2009. EMBO J. 28: 2244-58. PMID: 19590496
- AMPK-independent induction of autophagy by cytosolic Ca2+ increase. | Grotemeier, A., et al. 2010. Cell Signal. 22: 914-25. PMID: 20114074
- Starvation-induced hyperacetylation of tubulin is required for the stimulation of autophagy by nutrient deprivation. | Geeraert, C., et al. 2010. J Biol Chem. 285: 24184-94. PMID: 20484055
- The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. | Gao, P., et al. 2010. J Biol Chem. 285: 25570-81. PMID: 20529838
- Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. | Itakura, E. and Mizushima, N. 2010. Autophagy. 6: 764-76. PMID: 20639694
- The activation of autophagy protects neurons and astrocytes against bilirubin-induced cytotoxicity. | Qaisiya, M., et al. 2017. Neurosci Lett. 661: 96-103. PMID: 28965934
- RanBP3 Regulates Proliferation, Apoptosis and Chemosensitivity of Chronic Myeloid Leukemia Cells via Mediating SMAD2/3 and ERK1/2 Nuclear Transport. | Li, Q., et al. 2021. Front Oncol. 11: 698410. PMID: 34504783
- Comparing the Biology of Young versus Old Age Estrogen-Receptor-Positive Breast Cancer through Gene and Protein Expression Analyses. | Siddig, A., et al. 2023. Biomedicines. 11: PMID: 36672708
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WIPI-1 Antibody (38-W) | sc-100901 | 100 µg/ml | $339.00 |