WIP Antibody (E-9): sc-271114

WIP Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects WIP in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). WIP, or WAS-interacting protein, plays a crucial role in the regulation of actin dynamics and is essential for proper immune cell function. WIP (E-9) antibody recognizes multiple domains that facilitate actin-binding and interaction with signaling proteins, which are vital for T cell and B cell activation. The interaction between WIP and the Wiskott-Aldrich syndrome protein (WASP) is particularly significant, as this binding is necessary for the activation of NF-AT/AP-1 transcription factors, which are critical for T cell responses. Mutations in WASP can disrupt this complex, leading to immunodeficiency, highlighting the importance of WIP in maintaining immune system integrity. The gene encoding human WIP is located on chromosome 2p23.3-q24.3, and WIP expression is associated with increased F-actin content and morphological changes in B cells, further underscoring its role in cytoskeletal organization and immune function. Anti-WIP antibody (E-9) serves as an invaluable tool for researchers studying the mechanisms of immune response and the pathogenesis of immunodeficiencies.

The preferred WIP antibody is WIP Antibody (C-1): sc-390099.