Wig-1 Antibody (C-1): sc-398712
- Wig-1 Antibody (C-1) is a mouse monoclonal IgG2b κ Wig-1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 245-272 within an internal region of Wig-1 of mouse origin
- Wig-1 Antibody (C-1) is recommended for detection of Wig-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Wig-1 Antibody (C-1) is available conjugated to agarose for IP; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Wig-1 Antibody (C-1) for WB applications. This reagent is now offered in a bundle with Wig-1 Antibody (C-1) (see ordering information below).
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Wig-1 Antibody (C-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects Wig-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Wig-1 antibody (C-1) is available in both non-conjugated and various conjugated forms, including agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Wig-1, also known as wild type p53-induced gene 1, plays a crucial role in cellular responses to stress and DNA damage, acting as a transcriptional regulator induced by tumor suppressor protein p53. Wig-1 contains a zinc finger motif and a putative nuclear localization signal, essential for nuclear function in influencing gene expression. Wig-1 (C-1) antibody helps researchers study this protein′s involvement in apoptosis regulation and cell cycle progression, making Wig-1 significant in tumor suppression mechanisms. Wig-1 expression increases in response to gamma irradiation, highlighting Wig-1′s role in cellular response to DNA damage and genomic integrity maintenance. Using Wig-1 monoclonal antibody (C-1) enables valuable insights into pathways regulated by Wig-1 and implications in cancer biology and therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Wig-1 Antibody (C-1) References:
- p53 expression overcomes p21WAF1/CIP1-mediated G1 arrest and induces apoptosis in human cancer cells. | Kagawa, S., et al. 1997. Oncogene. 15: 1903-9. PMID: 9365236
- A new look at the role of p53 in leukemia cell sensitivity to chemotherapy. | Trepel, M., et al. 1997. Leukemia. 11: 1842-9. PMID: 9369416
- Wig-1, a new p53-induced gene encoding a zinc finger protein. | Varmeh-Ziaie, S., et al. 1997. Oncogene. 15: 2699-704. PMID: 9400996
- Keeping an old friend under control: regulation of p53 stability. | Kubbutat, MH. and Vousden, KH. 1998. Mol Med Today. 4: 250-6. PMID: 9679243
- A matter of life and cell death. | Evan, G. and Littlewood, T. 1998. Science. 281: 1317-22. PMID: 9721090
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wig-1 Antibody (C-1) | sc-398712 | 200 µg/ml | $322.00 | |||
Wig-1 Antibody (C-1): m-IgG2b BP-HRP Bundle | sc-548790 | 200 µg Ab; 10 µg BP | $361.00 | |||
Wig-1 Antibody (C-1) AC | sc-398712 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Wig-1 Antibody (C-1) FITC | sc-398712 FITC | 200 µg/ml | $336.00 | |||
Wig-1 Antibody (C-1) PE | sc-398712 PE | 200 µg/ml | $349.00 | |||
Wig-1 Antibody (C-1) Alexa Fluor® 488 | sc-398712 AF488 | 200 µg/ml | $364.00 | |||
Wig-1 Antibody (C-1) Alexa Fluor® 546 | sc-398712 AF546 | 200 µg/ml | $364.00 | |||
Wig-1 Antibody (C-1) Alexa Fluor® 594 | sc-398712 AF594 | 200 µg/ml | $364.00 | |||
Wig-1 Antibody (C-1) Alexa Fluor® 647 | sc-398712 AF647 | 200 µg/ml | $364.00 | |||
Wig-1 Antibody (C-1) Alexa Fluor® 680 | sc-398712 AF680 | 200 µg/ml | $364.00 | |||
Wig-1 Antibody (C-1) Alexa Fluor® 790 | sc-398712 AF790 | 200 µg/ml | $364.00 | |||
Wig-1 (C-1) Neutralizing Peptide | sc-398712 P | 100 µg/0.5 ml | $69.00 |