WDR92 Antibody (E-10): sc-376734

WDR92 Antibody (E-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects WDR92 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WDR92 (E-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WDR92, also known as WD repeat-containing protein Monad, is a 357 amino acid protein characterized by the presence of six WD-repeats, which are structural motifs that typically form a tertiary propeller configuration. These WD-repeats facilitate interactions with other proteins, playing a significant role in various cellular processes such as chromatin assembly, cell cycle regulation, and apoptosis. WDR92 expression is notably high in testicular tissue, suggesting involvement in reproductive processes and apoptosis regulation. WDR92 gene is located on human chromosome 2, a region associated with numerous genetic disorders, highlighting WDR92′s importance in both normal physiology and disease states.

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WDR92 Antibody (E-10) References:

1. The WD repeat: a common architecture for diverse functions.  |  Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
2. Alstrom syndrome: confirmation of linkage to chromosome 2p12-13 and phenotypic heterogeneity in three affected sibs.  |  Zumsteg, U., et al. 2000. J Med Genet. 37: E8. PMID: 10882760
3. An ATP-binding cassette gene (ABCG5) from the ABCG (White) gene subfamily maps to human chromosome 2p21 in the region of the Sitosterolemia locus.  |  Shulenin, S., et al. 2001. Cytogenet Cell Genet. 92: 204-8. PMID: 11435688
4. Complete sequencing and characterization of 21,243 full-length human cDNAs.  |  Ota, T., et al. 2004. Nat Genet. 36: 40-5. PMID: 14702039
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).  |  Gerhard, DS., et al. 2004. Genome Res. 14: 2121-7. PMID: 15489334
6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.  |  Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
7. The WD-40 repeat.  |  van der Voorn, L. and Ploegh, HL. 1992. FEBS Lett. 307: 131-4. PMID: 1644165
8. Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha.  |  Saeki, M., et al. 2006. Biochem Biophys Res Commun. 342: 568-72. PMID: 16487927
9. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP.  |  Zur Lage, P., et al. 2018. J Cell Biol. 217: 2583-2598. PMID: 29743191
10. Chlamydomonas WDR92 in association with R2TP-like complex and multiple DNAAFs to regulate ciliary dynein preassembly.  |  Liu, G., et al. 2019. J Mol Cell Biol. 11: 770-780. PMID: 30428028
11. WDR92 is required for axonemal dynein heavy chain stability in cytoplasm.  |  Patel-King, RS., et al. 2019. Mol Biol Cell. 30: 1834-1845. PMID: 31116681
12. The ancient regulatory-protein family of WD-repeat proteins.  |  Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WDR92 Antibody (E-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-WDR92 Antibody (E-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WDR92 Antibody (E-10) Specifications

Alternate Product Name: WDR92

Product Clone Name: E-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: WDR92

Epitope Species: human

Product Reactivity/Detection: WDR92

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for WDR92 Antibody (E-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin