WDR79 Antibody (1F12): sc-517078
- WDR79 Antibody (1F12) is a mouse monoclonal IgG2a κ WDR79 antibody provided at 100 µg/ml
- raised against amino acids 62-160 representing partial length WDR79 of human origin
- recommended for detection of WDR79 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for WDR79 Antibody (1F12). This work is in progress.
WDR79 Antibody (1F12) is a mouse monoclonal IgG2a kappa light chain antibody that detects WDR79 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-WDR79 antibody (1F12) is available as the non-conjugated format. WDR79, also known as TCAB1 or WRAP53, is a crucial 548 amino acid nuclear protein that plays a significant role in the telomerase holoenzyme complex, a ribonucleoprotein complex essential for chromosome termini replication and telomere elongation in most eukaryotes. WDR79 is predominantly located in the nucleus, where WDR79 regulates telomerase localization to Cajal bodies, which are subnuclear structures important for ribonucleoprotein complex assembly. Proper functioning of WDR79 maintains telomere integrity, critical for cellular aging and stability. WDR79 also regulates p53 mRNA levels, contributing to cellular response to DNA damage. WD-repeats in WDR79, characterized by a conserved core structure, enable participation in various regulatory mechanisms, including chromatin assembly and signal transduction, highlighting WDR79′s importance in cellular homeostasis and stress response.
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WDR79 Antibody (1F12) References:
- The WD-40 repeat. | van der Voorn, L. and Ploegh, HL. 1992. FEBS Lett. 307: 131-4. PMID: 1644165
- Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer. | Garcia-Closas, M., et al. 2007. Int J Cancer. 121: 2532-8. PMID: 17683073
- Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage. | Mahmoudi, S., et al. 2009. Mol Cell. 33: 462-71. PMID: 19250907
- A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles. | Tycowski, KT., et al. 2009. Mol Cell. 34: 47-57. PMID: 19285445
- Wrap53, a novel regulator of p53. | Farnebo, M. 2009. Cell Cycle. 8: 2343-6. PMID: 19571673
- The diversity profile of TP53 is influenced by positive selection on the immediately upstream locus WDR79. | Alonso, S., et al. 2010. Hum Hered. 69: 34-44. PMID: 19797907
- The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer. | Farnebo, M., et al. 2010. Biochem Biophys Res Commun. 396: 85-9. PMID: 20494116
- WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies. | Mahmoudi, S., et al. 2010. PLoS Biol. 8: e1000521. PMID: 21072240
- The ancient regulatory-protein family of WD-repeat proteins. | Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WDR79 Antibody (1F12) | sc-517078 | 100 µg/ml | $322.00 |