WDR62 Antibody (H-1): sc-514865

WDR62 Antibody (H-1) is a mouse monoclonal IgM kappa antibody that detects WDR62 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-WDR62 antibody (H-1) is available as the non-conjugated form. WDR62, also known as WD repeat domain 62 or C19orf14, is a crucial player in cellular regulation, consisting of 1,518 amino acids and featuring 15 WD repeats that contribute to its tertiary propeller structure. This unique structure is essential for its function in various cellular processes, including chromatin assembly, cell cycle control, and signal transduction. WDR62 is involved in the regulation of microtubule dynamics during cell division, which is vital for maintaining genomic stability. The gene encoding WDR62 is located on human chromosome 19 and gives rise to multiple alternatively spliced isoforms, further underscoring its regulatory complexity. The presence of WD repeats in WDR62 suggests its involvement in protein-protein interactions, making WDR62 a significant component in various signaling pathways.

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WDR62 Antibody (H-1) References:

1. The WD repeat: a common architecture for diverse functions.  |  Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
2. WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.  |  Li, D. and Roberts, R. 2001. Cell Mol Life Sci. 58: 2085-97. PMID: 11814058
3. The WD-40 repeat.  |  van der Voorn, L. and Ploegh, HL. 1992. FEBS Lett. 307: 131-4. PMID: 1644165
4. A novel WDR62 missense mutation in microcephaly with abnormal cortical architecture and review of the literature.  |  Zombor, M., et al. 2019. J Appl Genet. 60: 151-162. PMID: 30706430
5. Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases.  |  Zhi, Y., et al. 2021. Front Cell Dev Biol. 9: 640753. PMID: 33937237
6. WDR62 localizes katanin at spindle poles to ensure synchronous chromosome segregation.  |  Guerreiro, A., et al. 2021. J Cell Biol. 220: PMID: 34137788
7. WDR62 regulates mouse oocyte meiotic maturation related to p-JNK and H3K9 trimethylation.  |  Wang, YS., et al. 2022. Int J Biochem Cell Biol. 144: 106169. PMID: 35093571
8. WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation.  |  Hao, L., et al. 2022. Clin Transl Med. 12: e941. PMID: 35808830
9. WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice.  |  Xu, D., et al. 2023. Neurosci Bull. 39: 1333-1347. PMID: 36571716
10. The ancient regulatory-protein family of WD-repeat proteins.  |  Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199
11. Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.  |  Garcia-Higuera, I., et al. 1996. Biochemistry. 35: 13985-94. PMID: 8909296
12. Folding a WD repeat propeller. Role of highly conserved aspartic acid residues in the G protein beta subunit and Sec13.  |  Garcia-Higuera, I., et al. 1998. J Biol Chem. 273: 9041-9. PMID: 9535892

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WDR62 Antibody (H-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-WDR62 Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WDR62 Antibody (H-1) Specifications

Alternate Product Name: WDR62

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 66-84

Epitope Target: WDR62

Epitope Species: human

Product Reactivity/Detection: WDR62

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for WDR62 Antibody (H-1): P: Blocking Peptide